| Title: | Protective effect of thymoquinone against lung intoxication induced by malathion inhalation |
| Author(s): | Abdo W; Elmadawy MA; Abdelhiee EY; Abdel-Kareem MA; Farag A; Aboubakr M; Ghazy E; Fadl SE; |
| Address: | "Pathology Department, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafr Elsheikh, 33516, Egypt. Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafr Elsheikh, 33516, Egypt. Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Matrouh University, Matrouh, Egypt. Anatomy and Embryology Department, Faculty of Medicine, Kafrelsheikh University, Kafr Elsheikh, 33516, Egypt. Department of Pharmacology, Faculty of Veterinary Medicine, Banha University, 13736 Moshtohor, Toukh, Qaliobiya, Egypt. Clinical Pathology Department, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafr Elsheikh, 33516, Egypt. Biochemistry Department, Faculty of Veterinary Medicine, Matrouh University, Matrouh, Egypt. nourmallak@yahoo.com" |
| DOI: | 10.1038/s41598-021-82083-w |
| ISSN/ISBN: | 2045-2322 (Electronic) 2045-2322 (Linking) |
| Abstract: | "Malathion is considered one of the vastest pesticides use all over the world. Malathion-inhalation toxicity commonly occurred in many occupational farmers. Therefore, this study aimed to ameliorate the possible malathion-induced pulmonary toxicity through thymoquinone administration. Forty animals were used to conduct our study, divided into five groups; G1 control group, G2 thymoquinone (50 mg/kg) group, G3 malathion group (animals inhaled 100 mg/ml/m(3) for 15 min for 5 days/week for three weeks), G4 and G5 were subjected to the same malathion inhalation protocol beside oral thymoquinone administration at doses of 25 and 50 (mg/kg), respectively. Malathion-inhalation induced marked systemic toxicity as hepatotoxicity and nephrotoxicity associated with increased serum hepatic and renal enzymes, and hypersensitivity accompanied with increased total IgE serum level. The lung showed severe interstitial pneumonia associated with severe vascular damage and marked eosinophil infiltration. Moreover, the lung showed a marked decrease in the pulmonary surfactant protein, especially SP-D gene expression. While, thymoquinone treatment to malathion-inhaled animals decremented the following; hepatic enzymes and renal function tests, total IgE as well as pneumonia and hypersensitivity pathological features, and augmented the expression of SP-D. In conclusion, thymoquinone could be potentially used in pest control workers to ameliorate the systemic and pulmonary intoxication caused by one of the most field-used pesticides" |
| Keywords: | "Administration, Inhalation Animals Benzoquinones/*pharmacology *Lung Malathion/*adverse effects/pharmacology Male Oxidative Stress/*drug effects Pesticides/*adverse effects/pharmacology Rats Rats, Sprague-Dawley;" |
| Notes: | "MedlineAbdo, Walied Elmadawy, Mostafa A Abdelhiee, Ehab Yahya Abdel-Kareem, Mona A Farag, Amira Aboubakr, Mohamed Ghazy, Emad Fadl, Sabreen E eng England 2021/01/30 Sci Rep. 2021 Jan 28; 11(1):2498. doi: 10.1038/s41598-021-82083-w" |
