| Title: | "Association between the Occurrence of Primary Hypothyroidism and the Exposure of the Population Near to Industrial Pollutants in Sao Paulo State, Brazil" |
| Author(s): | Zaccarelli-Marino MA; Alessi R; Balderi TZ; Martins MAG; |
| Address: | "Internal Medicine Department, Endocrinology Service, ABC Medical School, Foundation, Santo Andre, SP 09060-870, Brazil. mangelazaccarelli@yahoo.com.br. Internal Medicine Department, ABC Medical School Foundation, Santo Andre, SP 09060-870, Brazil. ruda.alessi@gmail.com. Internal Medicine Service, Santa Paula Hospital, Sao Paulo, SP 04556-100, Brazil. thalles@institutoneurologico.com.br. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. mmartins@hsph.harvard.edu" |
| Journal Title: | Int J Environ Res Public Health |
| ISSN/ISBN: | 1660-4601 (Electronic) 1661-7827 (Print) 1660-4601 (Linking) |
| Abstract: | "BACKGROUND: Environmental agents interfere with thyroid function at multiple levels. This study was to investigate the association between pollutant concentrations and the primary hypothyroidism (PH) occurrence odds in residents living in the Capuava Petrochemical Complex (CPC) influence area. METHODS: This area was evaluated with the combination of the AERMOD dispersion model with the Weather Research Forecast (WRF) meteorological model (2016). The concentration of atmospheric pollutants were analyzed in 2017 using meteorological data on the period from 2005 to 2009, correlating this data with the research done in 2003 to 2005. A home-based questionnaire was applied to evaluate 2004 residents, of both sexes, aged from 8 to 72 years, based on their proximity to the industrial areas; were select residents with PH. RESULTS: Volatile organic compounds (VOCs), carbon monoxide (CO), and nitrogen dioxide (NO(2)) concentrations presented the highest correlations between the PH odds and pollutant concentrations. CONCLUSION: Air pollution associated with the presence of the CPC is an important environmental factor contributing to the development of PH in the nearby population. As the first study showing this association in Brazil, research should be continued to better understand the mechanisms and to find ways to compensate for or remedy to avoid health impacts in future populations" |
| Keywords: | "Adolescent Adult Aged Air Pollutants/*adverse effects Air Pollution/*adverse effects Brazil/epidemiology Child *Environmental Exposure Female Humans Hypothyroidism/chemically induced/*epidemiology Incidence Industry Male Middle Aged Models, Theoretical Pr;" |
| Notes: | "MedlineZaccarelli-Marino, Maria Angela Alessi, Ruda Balderi, Thalles Zaccarelli Martins, Marco Antonio Garcia eng Switzerland 2019/09/22 Int J Environ Res Public Health. 2019 Sep 18; 16(18):3464. doi: 10.3390/ijerph16183464" |
