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Trends Cell Biol

Title:		MAPK signaling specificity: it takes two to tango
Author(s):		Breitkreutz A; Tyers M;
Address:		"Samuel Lunenfeld Research Institute, Room 1080, Mt Sinai Hospital, Toronto, Canada"
Journal Title:		Trends Cell Biol
Year:		2002
Volume:		12
Issue:		6
Page Number:		254 - 257
DOI:		10.1016/s0962-8924(02)02284-5
ISSN/ISBN:		0962-8924 (Print) 0962-8924 (Linking)
Abstract:		"A surprisingly limited repertoire of core signaling pathways generates an enormous diversity of responses, often in a cell type-specific manner. Even within one cell, a single pathway might yield two different responses depending on the input signal. In budding yeast, a mitogen-activated protein kinase (MAPK) module seems to transmit both mating pheromone and invasive growth signals in the same yeast cell. We discuss recent insights into mechanisms of differential MAPK activation in this system"
Keywords:		"*Adaptor Proteins, Signal Transducing *Carrier Proteins Enzyme Activation *FMN Reductase *MAP Kinase Signaling System/drug effects Mating Factor Mitogen-Activated Protein Kinases/*metabolism NADH, NADPH Oxidoreductases/metabolism Peptides/pharmacology Rep;"
Notes:		"MedlineBreitkreutz, Ashton Tyers, Mike eng Research Support, Non-U.S. Gov't England 2002/06/21 Trends Cell Biol. 2002 Jun; 12(6):254-7. doi: 10.1016/s0962-8924(02)02284-5"