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Environ Pollut

Title:		"A cohort study of intra-urban variations in volatile organic compounds and mortality, Toronto, Canada"
Author(s):		Villeneuve PJ; Jerrett M; Su J; Burnett RT; Chen H; Brook J; Wheeler AJ; Cakmak S; Goldberg MS;
Address:		"Population Studies Division, Health Canada, Ottawa, Ontario, Canada; Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada. Electronic address: Paul_Villeneuve@hc-sc.gc.ca"
Journal Title:		Environ Pollut
Year:		2013
Volume:		20130129
Issue:
Page Number:		30 - 39
DOI:		10.1016/j.envpol.2012.12.022
ISSN/ISBN:		1873-6424 (Electronic) 0269-7491 (Linking)
Abstract:		"This study investigated associations between long-term exposure to ambient volatile organic compounds (VOCs) and mortality. 58,760 Toronto residents (>/=35 years of age) were selected from tax filings and followed from 1982 to 2004. Death information was extracted using record linkage to national mortality data. Land-use regression surfaces for benzene, n-hexane, and total hydrocarbons were generated from sampling campaigns in 2002 and 2004 and assigned to residential addresses in 1982. Cox regression was used to estimate relationships between each VOC and non-accidental, cardiovascular, and cancer mortality. Positive associations were observed for each VOC. In multi-pollutant models the benzene and total hydrocarbon signals were strongest for cancer. The hazard ratio for cancer that corresponded to an increase in the interquartile range of benzene (0.13 mug/m(3)) was 1.06 (95% CI = 1.02-1.11). Our findings suggest ambient concentrations of VOCs were associated with cancer mortality, and that these exposures did not confound our previously reported associations between NO2 and cardiovascular mortality"
Keywords:		"Adult Aged Aged, 80 and over Air Pollutants/analysis/*toxicity Air Pollution/*statistics & numerical data Cardiovascular Diseases/mortality Environmental Exposure/*statistics & numerical data Female Geographic Information Systems Humans Male Middle Aged N;"
Notes:		"MedlineVilleneuve, Paul J Jerrett, Michael Su, Jason Burnett, Richard T Chen, Hong Brook, Jeffrey Wheeler, Amanda J Cakmak, Sabit Goldberg, Mark S eng Canadian Institutes of Health Research/Canada Research Support, Non-U.S. Gov't England 2013/02/02 Environ Pollut. 2013 Dec; 183:30-9. doi: 10.1016/j.envpol.2012.12.022. Epub 2013 Jan 29"