| Title: | Chemosensory cues from the lacrimal and preputial glands stimulate production of IP3 in the vomeronasal organ and aggression in male mice |
| Author(s): | Thompson RN; Napier A; Wekesa KS; |
| Address: | "Alabama State University, Department of Biological Sciences, Montgomery, AL 36101-0271, USA" |
| DOI: | 10.1016/j.physbeh.2007.01.008 |
| ISSN/ISBN: | 0031-9384 (Print) 0031-9384 (Linking) |
| Abstract: | "The social and reproductive behaviors of most mammals are modulated by chemosensory cues. The perception of some of these cues is mediated by the vomeronasal organ, which is a cartilage-encased elongated organ associated with the vomer bone in the rostral nasal cavity. Several studies have shown that chemosensory cues are present in urine, seminal fluid or vaginal secretions but only a few studies have focused on exocrine glands as a source of chemosensory cues. Here we show that chemosensory cues present in two exocrine glands, i.e., the preputial gland located at the caudal region and the lacrimal gland located at the rostral region, are capable of stimulating aggression in male mice. We further show that these extracts can stimulate the production of inositol-(1,4,5)-trisphosphate in the vomeronasal organ" |
| Keywords: | "Aggression/*physiology Analysis of Variance Animals Chemoreceptor Cells/physiology Exocrine Glands/*metabolism/physiology In Vitro Techniques Inositol 1, 4, 5-Trisphosphate/*metabolism Lacrimal Apparatus/metabolism Male Mice Penis/metabolism Pheromones/*met;" |
| Notes: | "MedlineThompson, Roger N Napier, Audrey Wekesa, Kennedy S eng S06 GM008219/GM/NIGMS NIH HHS/ P20 MD000547-04/MD/NIMHD NIH HHS/ P20 MD000547/MD/NIMHD NIH HHS/ GM08219/GM/NIGMS NIH HHS/ S06 GM008219-220011/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural 2007/02/20 Physiol Behav. 2007 Apr 23; 90(5):797-802. doi: 10.1016/j.physbeh.2007.01.008. Epub 2007 Jan 20" |
