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J Comp Physiol A

Title:		Inositol-trisphosphate-dependent calcium currents precede cation currents in insect olfactory receptor neurons in vitro
Author(s):		Stengl M;
Address:		"Institut fur Zoologie, Universitat Regensburg, Germany"
Journal Title:		J Comp Physiol A
Year:		1994
Volume:		174
Issue:		2
Page Number:		187 - 194
DOI:		10.1007/BF00193785
ISSN/ISBN:
Abstract:		"Specialized olfactory receptor neurons in insects respond to species-specific sex pheromones with transient rises in inositol trisphosphate and by opening pheromone-dependent cation channels. These channels resemble cation channels which are directly or indirectly Ca(2+)-dependent. But there appear to be no internal Ca2+ stores in the outer dendrite where the olfactory transduction cascade is thought to start. Hence, it remains to be determined whether an influx of external Ca2+ precedes pheromone-dependent cation currents. Patch clamp measurements in cultured olfactory receptor neurons from Manduca sexta reveal that a transient inward current precedes pheromone-dependent cation currents. A transient inositol trisphosphate-dependent Ca2+ current, also preceding cation currents with the characteristics of pheromone-dependent cation currents, shares properties with the transient pheromone-dependent current. These results match the biochemical measurements with the electrophysiological data obtained in insect olfactory receptor neurons"
Keywords:		"Animals Calcium Channels/drug effects/*physiology Cells, Cultured Electrophysiology Inosine Triphosphate/*physiology Ion Channels/drug effects/*physiology Membrane Potentials/drug effects/physiology Moths/*physiology Neurons, Afferent/drug effects/*physio;"
Notes:		"MedlineStengl, M eng AI-23253/AI/NIAID NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Germany 1994/02/01 J Comp Physiol A. 1994 Feb; 174(2):187-94. doi: 10.1007/BF00193785"