| Title: | Chirality Effects on Repellent Properties of 4-Alkoxycoumarins Against Asian Tiger Mosquito (Diptera: Culicidae) |
| Author(s): | Ramiharimanana FD; Andrianjafy MT; Ramarosandratana NH; Andrianarijaona TE; Rambala Rakotomena NAH; Metay E; Duclos MC; Cinquin V; Mavingui P; Vestalys Ramanandraibe V; Lemaire M; |
| Address: | "International Associated Laboratory, University of Antananarivo-Lyon 1, Antananarivo, Madagascar. Department of Entomology, University of Antananarivo, Antananarivo, Madagascar. ICBMS, CNRS, UMR 5246, University of Claude Bernard Lyon, 1 Rue Victor Grignard, Batiment Lederer, 69622, Villeurbanne Cedex, France. University of Reunion, UMR PIMIT, INSERM 1187, CNRS 9192, IRD 249, Plateforme Technologique CYROI, 2 Rue Maxime Riviere Sainte Clotilde, La Reunion, France" |
| ISSN/ISBN: | 1938-2928 (Electronic) 0022-2585 (Linking) |
| Abstract: | "The use of semiochemicals as repellents and attractants has been proposed to complement insecticides used for the control of vector mosquito populations. In several studies, the optical purities of the molecules tested have been described as having little or no effect on repellent activity. However, these observations seem difficult to explain because of the chirality effect of molecules on the olfactory system of insects and humans. Thus, the purpose of this study is to assess the effects of chirality on the repellent properties of 4-alcoxycoumarins against Aedes albopictus Skuse, mosquito vector of arboviruses. We report here that the racemic (R/S)-4-sec-butoxycoumarin had the highest repellent effect (Repellent Index = 49.9%) followed by (R) enantiomer (Repellent Index = 24.2%) for the dose of 5 mg/mL. Contrary, no significant repellent activity was recorded for S-(+)-4-sec-butoxycoumarin. This experiment demonstrates the close relationship between the molecules' optical purities and the behavioral response of mosquitoes" |
| Keywords: | *Aedes Animals *Culicidae Disease Vectors *Insect Repellents/chemistry *Insecticides/pharmacology Mosquito Vectors 4-alkoxycoumarin Asian tiger mosquito chirality repellent synthesis; |
| Notes: | "MedlineRamiharimanana, Fenia Diane Andrianjafy, Mbolatiana Tovo Ramarosandratana, Niry Hasinandrianina Andrianarijaona, Toavina Elodie Rambala Rakotomena, Ny Aina Harivony Metay, Estelle Duclos, Marie-Christine Cinquin, Valentin Mavingui, Patrick Vestalys Ramanandraibe, Voahangy Lemaire, Marc eng International Associated Laboratory/ England 2022/01/19 J Med Entomol. 2022 Mar 16; 59(2):430-439. doi: 10.1093/jme/tjab176" |
