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Anal Bioanal Chem

Title:		Non-volatile compounds in exhaled breath condensate: review of methodological aspects
Author(s):		Rahimpour E; Khoubnasabjafari M; Jouyban-Gharamaleki V; Jouyban A;
Address:		"Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. ajouyban@hotmail.com. Kimia Idea Pardaz Azarbayjan (KIPA) Science Based Company, Tabriz University of Medical Sciences, Tabriz, Iran. ajouyban@hotmail.com"
Journal Title:		Anal Bioanal Chem
Year:		2018
Volume:		20180725
Issue:		25
Page Number:		6411 - 6440
DOI:		10.1007/s00216-018-1259-4
ISSN/ISBN:		1618-2650 (Electronic) 1618-2642 (Linking)
Abstract:		"In contrast to bronchial and nasal lavages, the analysis of exhaled breath condensate (EBC) is a promising, simple, non-invasive, repeatable, and diagnostic method for studying the composition of airway lining fluid with the potential to assess lung inflammation, exacerbations, and disease severity, and to monitor the effectiveness of treatment regimens. Recent investigations have revealed the potential applications of EBC analysis in systemic diseases. In this review, we highlight the analytical studies conducted on non-volatile compounds/biomarkers in EBC. In contrast to other related articles, this review is classified on the basis of analytical techniques and includes almost all the applied methods and their methodological limitations for quantification of non-volatile compounds in EBC samples, providing a guideline for further researches. The studies were identified by searching the SCOPUS database with the keywords 'biomarkers,' 'non-volatile compounds,' 'determination method,' and 'EBC.'"
Keywords:		Biomarkers/analysis/*chemistry Breath Tests/*methods Carcinoembryonic Antigen Humans Neoplasms/diagnosis Virus Diseases/diagnosis Volatile Organic Compounds/chemistry Analytical methods Biomarkers Exhaled breath condensate Non-volatile compounds;
Notes:		"MedlineRahimpour, Elaheh Khoubnasabjafari, Maryam Jouyban-Gharamaleki, Vahid Jouyban, Abolghasem eng Review Germany 2018/07/27 Anal Bioanal Chem. 2018 Oct; 410(25):6411-6440. doi: 10.1007/s00216-018-1259-4. Epub 2018 Jul 25"