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Curr Opin Pulm Med

Title:		Metabolomics in asthma: where do we stand?
Author(s):		Pite H; Morais-Almeida M; Rocha SM;
Address:		"Allergy Center, CUF Descobertas Hospital and CUF Infante Santo Hospital. CEDOC, Chronic Diseases Research Center, NOVA Medical School/Faculdade de Ciencias Medicas, Universidade Nova de Lisboa, Lisbon. Department of Chemistry & QOPNA, University of Aveiro, Aveiro, Portugal"
Journal Title:		Curr Opin Pulm Med
Year:		2018
Volume:		24
Issue:		1
Page Number:		94 - 103
DOI:		10.1097/MCP.0000000000000437
ISSN/ISBN:		1531-6971 (Electronic) 1070-5287 (Linking)
Abstract:		"PURPOSE OF REVIEW: Metabolomics has been used to uncover the metabolic signatures of asthma, both for biomarker identification and pathophysiologic mechanisms research. We aimed to review recent advances in this field, published since 2016, and discuss these findings implications to future research and application into clinical practice. RECENT FINDINGS: Experimental asthma models and clinical studies in both children and adults supported independent metabolic signatures of asthma. Common reported pathways included purine, glycerophospholipid, glutathione, fatty acids, and arginine and proline metabolism. Metabolomics-based studies identified candidate biomarkers related to asthma severity and corticosteroid resistance, and supported the definition of the obesity-related phenotype at the molecular level. A systematic review with meta-analysis and recent prospective studies favored exhaled volatile organic compounds as one of the most promising biomarkers in asthma diagnosis and monitoring. SUMMARY: Metabolomics has provided unique and novel insights into asthma profiling at the molecular level. Current challenges include procedures standardization and control of potentially confounding variables for external validation. Point-of-care technology developments bring metabolomics closer to clinical practice. In addition to biomarkers identification, relating metabolites to their biologic role will serve as critical foundations for understanding the biology underpinning asthma heterogeneity and for specific-targeted therapies. VIDEO ABSTRACT"
Keywords:		Adrenal Cortex Hormones/*metabolism Asthma/*metabolism/physiopathology Biomarkers/metabolism Exhalation Humans *Metabolomics/trends Obesity/*metabolism/physiopathology Phenotype Predictive Value of Tests Purines/*metabolism Volatile Organic Compounds/*met;
Notes:		"MedlinePite, Helena Morais-Almeida, Mario Rocha, Silvia M eng Review Systematic Review Video-Audio Media 2017/10/24 Curr Opin Pulm Med. 2018 Jan; 24(1):94-103. doi: 10.1097/MCP.0000000000000437"