| Title: | Canine olfactory detection of SARS-CoV-2-infected humans-a systematic review |
| Author(s): | Meller S; Caraguel C; Twele F; Charalambous M; Schoneberg C; Chaber AL; Desquilbet L; Grandjean D; Mardones FO; Kreienbrock L; de la Rocque S; Volk HA; |
| Address: | "Department of Small Animal Medicine & Surgery, University of Veterinary Medicine Hannover, Hannover, Germany. Electronic address: sebastian.meller@tiho-hannover.de. School of Animal and Veterinary Sciences, The University of Adelaide, Adelaide, South Australia, Australia; OIE Diagnostic Test Validation Science in the Asia-Pacific Region, The University of Melbourne, Melbourne, Victoria, Australia. Department of Small Animal Medicine & Surgery, University of Veterinary Medicine Hannover, Hannover, Germany. Department of Biometry, Epidemiology and Information Processing, WHO Collaborating Centre for Research and Training for Health in the Human-Animal-Environment Interface, University of Veterinary Medicine Hannover, Hannover, Germany. School of Animal and Veterinary Sciences, The University of Adelaide, Adelaide, South Australia, Australia. Ecole Nationale Veterinaire d'Alfort, IMRB, Universite Paris-Est, Maisons-Alfort, France. Ecole Nationale Veterinaire d'Alfort, Universite Paris-Est, Maisons-Alfort, France. Escuela de Medicina Veterinaria, Facultad de Agronomia e Ingenieria Forestal, Facultad de Ciencias Biologicas y Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago de Chile, Chile. Human Animal Interface, WHO Health Emergencies Programme, Geneva, Switzerland. Department of Small Animal Medicine & Surgery, University of Veterinary Medicine Hannover, Hannover, Germany; Center for Systems Neuroscience, Hannover, Germany" |
| DOI: | 10.1016/j.annepidem.2023.05.002 |
| ISSN/ISBN: | 1873-2585 (Electronic) 1047-2797 (Print) 1047-2797 (Linking) |
| Abstract: | "PURPOSE: To complement conventional testing methods for severe acute respiratory syndrome coronavirus type 2 infections, dogs' olfactory capability for true real-time detection has been investigated worldwide. Diseases produce specific scents in affected individuals via volatile organic compounds. This systematic review evaluates the current evidence for canine olfaction as a reliable coronavirus disease 2019 screening tool. METHODS: Two independent study quality assessment tools were used: the QUADAS-2 tool for the evaluation of laboratory tests' diagnostic accuracy, designed for systematic reviews, and a general evaluation tool for canine detection studies, adapted to medical detection. Various study design, sample, dog, and olfactory training features were considered as potential confounding factors. RESULTS: Twenty-seven studies from 15 countries were evaluated. Respectively, four and six studies had a low risk of bias and high quality: the four QUADAS-2 nonbiased studies resulted in ranges of 81%-97% sensitivity and 91%-100% specificity. The six high-quality studies, according to the general evaluation system, revealed ranges of 82%-97% sensitivity and 83%-100% specificity. The other studies contained high bias risks and applicability and/or quality concerns. CONCLUSIONS: Standardization and certification procedures as used for canine explosives detection are needed for medical detection dogs for the optimal and structured usage of their undoubtful potential" |
| Keywords: | Covid-19 Canine scent detection Diagnostic test evaluation Dog Quadas-2 SARS-CoV-2; |
| Notes: | "PublisherMeller, Sebastian Caraguel, Charles Twele, Friederike Charalambous, Marios Schoneberg, Clara Chaber, Anne-Lise Desquilbet, Loic Grandjean, Dominique Mardones, Fernando O Kreienbrock, Lothar de la Rocque, Stephane Volk, Holger A eng 001/WHO_/World Health Organization/International Review 2023/05/21 Ann Epidemiol. 2023 Sep; 85:68-85. doi: 10.1016/j.annepidem.2023.05.002. Epub 2023 May 19" |
