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Trends Cell Biol

Title:		The control of filamentous differentiation and virulence in fungi
Author(s):		Madhani HD; Fink GR;
Address:		"Whitehead Institute for Biomedical Research, Nine Cambridge Center, MA 02142, USA. madhani@wi.mit.edu"
Journal Title:		Trends Cell Biol
Year:		1998
Volume:		8
Issue:		9
Page Number:		348 - 353
DOI:		10.1016/s0962-8924(98)01298-7
ISSN/ISBN:		0962-8924 (Print) 0962-8924 (Linking)
Abstract:		"Many members of the fungal kingdom have a distinguishing feature, dimorphism, which is the ability to switch between two morphological forms: a cellular yeast form and a multicellular invasive filamentous form. At least three pathways are involved in regulating the transition between these two forms in the budding yeast Saccharomyces cerevisiae, and evidence is now emerging that homologous signalling modules are involved in regulating filament formation and virulence in a range of human and plant fungal pathogens. Strikingly, components used to signal sexual differentiation in the response to mating pheromones are often reutilized to regulate dimorphic development, suggesting an ancient link between these processes"
Keywords:		Calcium-Calmodulin-Dependent Protein Kinases/physiology Fungi/*cytology/*pathogenicity Signal Transduction/physiology Virulence Yeasts/cytology;
Notes:		"MedlineMadhani, H D Fink, G R eng Review England 1998/09/05 Trends Cell Biol. 1998 Sep; 8(9):348-53. doi: 10.1016/s0962-8924(98)01298-7"