« Previous AbstractA dual-functional hydrogel for efficient water purification: Integrating solar interfacial evaporation with fenton reaction    Next AbstractEffect of potassium persulphate addition on sludge disintegration of a mesophilic anaerobic fermentation system »

J Sep Sci

Title:		Determination of nine volatile N-nitrosamines in tobacco and smokeless tobacco products by dispersive solid-phase extraction with gas chromatography and tandem mass spectrometry
Author(s):		Lv F; Guo J; Yu F; Zhang T; Zhang S; Cui H; Liu X; Chen L; Liu L; Liu S; Xie F;
Address:		"Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, China. China Tobacco Zhejiang Industrial Co., Ltd, Hangzhou, China. Gold leaf Manufacturing Center of China Tobacco Henan Industrial Co., Ltd, Zhengzhou, China. Technique Center of Tobacco Production, PingDingshan Tobacco Company of Henan Tobacco Monopoly Bureau, PingDingshan, China"
Journal Title:		J Sep Sci
Year:		2016
Volume:		20160428
Issue:		11
Page Number:		2123 - 2128
DOI:		10.1002/jssc.201600037
ISSN/ISBN:		1615-9314 (Electronic) 1615-9306 (Linking)
Abstract:		"A method was developed for the determination of nine volatile N-nitrosamines in tobacco and smokeless tobacco products. The targets are N-nitrosodimethylamine, N-nitrosopyrrolidine, N-nitrosopiperidine, N-nitrosomorpholine, N-nitrosoethylmethylamine, N-nitrosodiethylamine, N-nitrosodipropylamine, N-nitrosobuylmethylmine, and N-nitrosodibutylamine. The samples were treated by dispersive solid-phase extraction using 1 g of primary secondary amine and 0.5 g of carbon and then analyzed by gas chromatography with tandem mass spectrometry with an electron impact ion source. The recoveries for the targets ranged from 84 to 118%, with <16% relative standard deviations at three spiking levels of 0.5, 1.25, and 2.5 ng/g. The limits of detection ranged from 0.03 to 0.15 ng/g. With the use of the proposed method, we detected the presence of six nitrosamines in the range of 0.4-30.7 ng/g. The study demonstrated that the method could be used as a rapid, convenient, and high-throughput method for N-nitrosamines analysis in tobacco matrix"
Keywords:		"Chromatography, Gas Nitrosamines/*analysis *Solid Phase Extraction Tandem Mass Spectrometry Tobacco/*chemistry Tobacco Products/*analysis Tobacco, Smokeless/*analysis Volatile Organic Compounds/*analysis Dispersive solid-phase extraction Gas chromatograph;"
Notes:		"MedlineLv, Fang Guo, Junwei Yu, Fei Zhang, Tingting Zhang, Shimin Cui, Huapeng Liu, Xianjun Chen, Li Liu, Leiyu Liu, Shaofeng Xie, Fuwei eng Germany 2016/04/10 J Sep Sci. 2016 Jun; 39(11):2123-8. doi: 10.1002/jssc.201600037. Epub 2016 Apr 28"