| Title: | Diagnosis Biomarkers of Cholangiocarcinoma in Human Bile: An Evidence-Based Study |
| Author(s): | Bao F; Liu J; Chen H; Miao L; Xu Z; Zhang G; |
| Address: | "Institute of Integrative Medicine, Dalian Medical University, No. 9, South Road of Lvshun, Dalian 116044, China. Department of General Surgery, Pancreatic-Biliary Center, The First Affiliated Hospital of Dalian Medical University, No. 222, Zhongshan Road, Dalian 116011, China. CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China" |
| ISSN/ISBN: | 2072-6694 (Print) 2072-6694 (Electronic) 2072-6694 (Linking) |
| Abstract: | "Cholangiocarcinoma (CCA) is a multifactorial malignant tumor of the biliary tract, and the incidence of CCA is increasing in recent years. At present, the diagnosis of CCA mainly depends on imaging and invasive examination, with limited specificity and sensitivity and late detection. The early diagnosis of CCA always faces the dilemma of lacking specific diagnostic biomarkers. Non-invasive methods to assess the degree of CAA have been developed throughout the last decades. Among the many specimens looking for CCA biomarkers, bile has gotten a lot of attention lately. This paper mainly summarizes the recent developments in the current research on the diagnostic biomarkers for CCA in human bile at the levels of the gene, protein, metabolite, extracellular vesicles and volatile organic compounds" |
| Keywords: | bile biomarker cholangiocarcinoma diagnosis; |
| Notes: | "PubMed-not-MEDLINEBao, Fang Liu, Jiayue Chen, Haiyang Miao, Lu Xu, Zhaochao Zhang, Guixin eng 82174136/National Natural Science Foundation of China/ Review Switzerland 2022/08/27 Cancers (Basel). 2022 Aug 13; 14(16):3921. doi: 10.3390/cancers14163921" |
