| Title: | Bioactive mesoporous silica nanostructures with anti-microbial and anti-biofilm properties |
| Author(s): | Balaure PC; Boarca B; Popescu RC; Savu D; Trusca R; Vasile BS; Grumezescu AM; Holban AM; Bolocan A; Andronescu E; |
| Address: | "Department of Organic Chemistry, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania. Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania. Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania; Department of Life and Environmental Physics, 'Horia Hulubei' National Institute for Physics and Nuclear Engineering, Magurele, Bucharest, Romania. Department of Life and Environmental Physics, 'Horia Hulubei' National Institute for Physics and Nuclear Engineering, Magurele, Bucharest, Romania. Division of Earth, Environmental and Life Sciences, Research Institute of the University of Bucharest (ICUB), Bucharest, Romania. Electronic address: grumezescu@yahoo.com. Division of Earth, Environmental and Life Sciences, Research Institute of the University of Bucharest (ICUB), Bucharest, Romania; Microbiology and Immunology Department, Faculty of Biology, University of Bucharest, Bucharest, Romania. Emergency University Hospital, Bucharest, Romania; 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania" |
| DOI: | 10.1016/j.ijpharm.2017.08.062 |
| ISSN/ISBN: | 1873-3476 (Electronic) 0378-5173 (Linking) |
| Abstract: | "The increasing rate of antibiotic resistant bacteria associated with nosocomial infections in severely ill patients has urged the need for new antibacterial therapies. Nanostructured materials represent emerging innovative approaches to controlled delivery of different antimicrobial drugs. Delivery systems encapsulating natural compounds with antibacterial effects, such as essential oils have shown a great potential. Herein we report the development of SiO(2) mesoporous nanosystems loaded with eucalyptus (EUC), orange (ORA), and cinnamon (CIN) essential oils. These systems were characterized with respect to morphology (using scanning electron microscopy, SEM, and transmission electron microscopy, TEM), porosity (by BET and TEM analysis), chemical composition (by X-ray diffraction, XRD, and Fourier transform infrared spectrometry, FTIR) and loading capacity (by thermogravimetric analysis, TGA). The anti-bacterial and anti-adherence effects were tested against clinically relevant microbial species (Staphylococcus aureus ATCC 25923; Escherichia coli ATCC 25922; and Candida albicans ATCC 10231), while the biocompatibility was evaluated by in vitro tests with L929 mouse fibroblast cells" |
| Keywords: | "Animals Anti-Infective Agents/*chemistry Biofilms/*drug effects Candida albicans/drug effects Cell Line Cross Infection *Drug Delivery Systems Escherichia coli/drug effects Fibroblasts/drug effects Mice Nanostructures/*chemistry Oils, Volatile/pharmacolog;" |
| Notes: | "MedlineBalaure, Paul Catalin Boarca, Bianca Popescu, Roxana Cristina Savu, Diana Trusca, Roxana Vasile, Bogdan Stefan Grumezescu, Alexandru Mihai Holban, Alina Maria Bolocan, Alexandra Andronescu, Ecaterina eng Netherlands 2017/08/12 Int J Pharm. 2017 Oct 5; 531(1):35-46. doi: 10.1016/j.ijpharm.2017.08.062. Epub 2017 Aug 7" |
