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Respir Physiol Neurobiol

Title:		Gender and age specific differences in exhaled isoprene levels
Author(s):		Lechner M; Moser B; Niederseer D; Karlseder A; Holzknecht B; Fuchs M; Colvin S; Tilg H; Rieder J;
Address:		"Department of Hygiene, Microbiology, and Social Medicine, Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Fritz-Pregl-Strasse 3, A-6020 Innsbruck, Austria"
Journal Title:		Respir Physiol Neurobiol
Year:		2006
Volume:		20060228
Issue:		3
Page Number:		478 - 483
DOI:		10.1016/j.resp.2006.01.007
ISSN/ISBN:		1569-9048 (Print) 1569-9048 (Linking)
Abstract:		"The analysis of volatile organic compounds (VOC) in the human breath has attracted a considerable amount of clinical and scientific interest during the last decade. In our study, we turned our attention to gender and age specific differences of exhaled volatile compounds, particularly on isoprene which is one of the most abundant organic molecules found in human exhaled air. A total of 126 test persons were enrolled in the study: 66 females and 60 males. Moreover, the participants were classified into six groups with regard to their age. In a standardized setting all of them had to exhale the endexpiratory breath into a sample bag. The volatile compounds at m/z values from 21 to 229 were analyzed by using proton-transfer-reaction-mass-spectrometry. Isoprene (at m/z 69) was found to be highly significantly (p<0.001) elevated in the exhaled air of male subjects. Furthermore, it could be shown that 19-29 years old subjects exhale significantly lower levels of isoprene than older adults (p=0.002). No significant differences between groups were detected for any other measured mass. In conclusion, the present study demonstrates gender and age specific differences of isoprene levels in the exhaled air. These findings may be of potential clinical relevance regarding the multifaceted roles of isoprene, representing both indicator and effector molecule"
Keywords:		Adult Aged *Aging Breath Tests *Butadienes *Exhalation Female *Hemiterpenes Humans Male Mass Spectrometry/methods Middle Aged *Pentanes *Sex Characteristics;
Notes:		"MedlineLechner, Matthias Moser, Berthold Niederseer, David Karlseder, Alban Holzknecht, Bernhard Fuchs, Matthias Colvin, Stephan Tilg, Herbert Rieder, Josef eng Research Support, Non-U.S. Gov't Netherlands 2006/03/03 Respir Physiol Neurobiol. 2006 Dec; 154(3):478-83. doi: 10.1016/j.resp.2006.01.007. Epub 2006 Feb 28"