| Title: | "Lipopolysaccharide and a social stressor influence behaviour, corticosterone and cytokine levels: divergent actions in cyclooxygenase-2 deficient mice and wild type controls" |
| Author(s): | Hayley S; Mangano E; Strickland M; Anisman H; |
| Address: | "Institute of Neuroscience, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada K1S 5B6. shayley@ccs.carleton.ca" |
| DOI: | 10.1016/j.jneuroim.2008.03.015 |
| ISSN/ISBN: | 0165-5728 (Print) 0165-5728 (Linking) |
| Abstract: | "Administration of the endotoxin, lipopolysaccharide (LPS) diminished motor activity and increased plasma corticosterone as well as circulating levels of interleukin-1beta (IL-1beta), IL-6, tumor necrosis-factor-alpha (TNF-alpha) and IL-10. Among cyclooxygenase-2 (COX-2) knockout mice the behavioural, corticosterone and cytokine variations promoted by LPS were moderately (home cage activity, corticosterone, TNF-alpha) or largely (IL-6) reduced. However, if mice were exposed to a psychosocial stressor (social disruption associated with grouping mice with novel cage-mates after a period of isolation) coupled with LPS treatment, then the effects of the COX-2 deletion were absent, or there was a synergistic or additive elevation apparent (e.g., in the case of TNF-alpha, IL-6 and corticosterone). Evidently, COX-2 deletion may have either pro- or anti-inflammatory actions, depending upon the psychosocial context in which immune activation occurs" |
| Keywords: | "Animals *Behavior, Animal Corticosterone/*biosynthesis/blood Cyclooxygenase 2/*deficiency/genetics/physiology Cytokines/*biosynthesis/blood Housing, Animal Inflammation Mediators/physiology Interleukin-6/antagonists & inhibitors/blood Lipopolysaccharides/;neuroscience;" |
| Notes: | "MedlineHayley, Shawn Mangano, Emily Strickland, Michael Anisman, Hymie eng Research Support, Non-U.S. Gov't Netherlands 2008/05/06 J Neuroimmunol. 2008 Jun 15; 197(1):29-36. doi: 10.1016/j.jneuroim.2008.03.015. Epub 2008 May 2" |
