2023

When yeast cells change their mind: cell cycle 'Start' is reversible under starvation

2020

Rhizobacterium-derived diacetyl modulates plant immunity in a phosphate-dependent manner

Osmostress enhances activating phosphorylation of Hog1 MAP kinase by mono-phosphorylated Pbs2 MAP2K

2019

"Single-cell damage elicits regional, nematode-restricting ethylene responses in roots"

2018

Guanylyl cyclase-G is an alarm pheromone receptor in mice

Feeding state regulates pheromone-mediated avoidance behavior via the insulin signaling pathway in Caenorhabditis elegans

2012

The CatSper channel: a polymodal chemosensor in human sperm

Sperm are promiscuous and CatSper is to blame

2009

A constitutively active GPCR governs morphogenic transitions in Cryptococcus neoformans

2007

Gene cluster lock after pheromone receptor gene choice

2006

Opaque cells signal white cells to form biofilms in Candida albicans

A streptococcal protease that degrades CXC chemokines and impairs bacterial clearance from infected tissues

2004

Site-specific regulation of the GEF Cdc24p by the scaffold protein Far1p during yeast mating

2003

Monopolar spindle attachment of sister chromatids is ensured by two distinct mechanisms at the first meiotic division in fission yeast

An unusual MAP kinase is required for efficient penetration of the plant surface by Ustilago maydis

PKA and MAPK phosphorylation of Prf1 allows promoter discrimination in Ustilago maydis

2002

A positive feedback loop stabilizes the guanine-nucleotide exchange factor Cdc24 at sites of polarization

RNA editing by ADARs is important for normal behavior in Caenorhabditis elegans

"The Ppz protein phosphatases are key regulators of K+ and pH homeostasis: implications for salt tolerance, cell wall integrity and cell cycle progression"

2001

Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans

The eukaryotic response regulator Skn7p regulates calcineurin signaling through stabilization of Crz1p

2000

Nuclear-specific degradation of Far1 is controlled by the localization of the F-box protein Cdc4

An intact SH3 domain is required for myosin I-induced actin polymerization

N-acyl homoserine lactone binding to the CarR receptor determines quorum-sensing specificity in Erwinia

SCF(Met30)-mediated control of the transcriptional activator Met4 is required for the G(1)-S transition

1999

A constitutively active G-protein-coupled receptor causes mating self-compatibility in the mushroom Coprinus

Interaction of the yeast gamma-tubulin complex-binding protein Spc72p with Kar1p is essential for microtubule function during karyogamy

"A novel regulator of G protein signalling in yeast, Rgs2, downregulates glucose-activation of the cAMP pathway through direct inhibition of Gpa2"

The Sch9 protein kinase regulates Hsp90 chaperone complex signal transduction activity in vivo

1998

The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae

Serum response factor is essential for mesoderm formation during mouse embryogenesis

"RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation"

1997

Meiotic nuclear reorganization: switching the position of centromeres and telomeres in the fission yeast Schizosaccharomyces pombe

Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA

Differential targeting of closely related ECM glycoproteins: the pherophorin family from Volvox

Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase

Co-translational protein targeting catalyzed by the Escherichia coli signal recognition particle and its receptor

G proteins in Ustilago maydis: transmission of multiple signals?

Fission yeast pheromone blocks S-phase by inhibiting the G1 cyclin B-p34cdc2 kinase

"Identification of partners of TIF34, a component of the yeast eIF3 complex, required for cell proliferation and translation initiation"

The pheromone response pathway activates transcription of Ty5 retrotransposons located within silent chromatin of Saccharomyces cerevisiae

Suppressors of YCK-encoded yeast casein kinase 1 deficiency define the four subunits of a novel clathrin AP-like complex

1996

Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast

The pheromone response factor coordinates filamentous growth and pathogenicity in Ustilago maydis

The SLT2(MPK1) MAP kinase is activated during periods of polarized cell growth in yeast

1995

Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating

"The absence of Emp24p, a component of ER-derived COPII-coated vesicles, causes a defect in transport of selected proteins to the Golgi"

The mating-type locus B alpha 1 of Schizophyllum commune contains a pheromone receptor gene and putative pheromone genes

Roles and regulation of Cln-Cdc28 kinases at the start of the cell cycle of Saccharomyces cerevisiae

1994

Mating type-specific cell-cell recognition of Saccharomyces cerevisiae: cell wall attachment and active sites of a- and alpha-agglutinin

Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands

"Isolation and characterization of krp, a dibasic endopeptidase required for cell viability in the fission yeast Schizosaccharomyces pombe"

"MSG5, a novel protein phosphatase promotes adaptation to pheromone response in S. cerevisiae"

Heterodimerization of the yeast MATa1 and MAT alpha 2 proteins is mediated by two leucine zipper-like coiled-coil motifs

The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants

Calcium-independent calmodulin requirement for endocytosis in yeast

"Molecular characterization of SIG1, a Saccharomyces cerevisiae gene involved in negative regulation of G-protein-mediated signal transduction"

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues

VPS21 encodes a rab5-like GTP binding protein that is required for the sorting of yeast vacuolar proteins

Possible pheromone-carrier function of two lipocalin proteins in the vomeronasal organ

A zinc finger protein controls the onset of premeiotic DNA synthesis of fission yeast in a Mei2-independent cascade

The Saccharomyces cerevisiae APS1 gene encodes a homolog of the small subunit of the mammalian clathrin AP-1 complex: evidence for functional interaction with clathrin at the Golgi complex

Pheromones trigger filamentous growth in Ustilago maydis

1993

Isolation and characterization of S. cerevisiae mutants defective in somatostatin expression: cloning and functional role of a yeast gene encoding an aspartyl protease in precursor processing at monobasic cleavage sites

"CDC39, an essential nuclear protein that negatively regulates transcription and differentially affects the constitutive and inducible HIS3 promoters"

Brefeldin A reversibly blocks early but not late protein transport steps in the yeast secretory pathway

The lux autoinducer regulates the production of exoenzyme virulence determinants in Erwinia carotovora and Pseudomonas aeruginosa

Actin and fimbrin are required for the internalization step of endocytosis in yeast

Molecular genetic analysis of a locus required for resistance to antimicrobial peptides in Salmonella typhimurium

How a sex pheromone might act at a concentration below 10(-16) M

"Comparison of the Saccharomyces cerevisiae G1 cyclins: Cln3 may be an upstream activator of Cln1, Cln2 and other cyclins"

"Vps1p, a member of the dynamin GTPase family, is necessary for Golgi membrane protein retention in Saccharomyces cerevisiae"

1992

Dual functions of CDC6: a yeast protein required for DNA replication also inhibits nuclear division

Mating pheromones of the fission yeast Schizosaccharomyces pombe: purification and structural characterization of M-factor and isolation and analysis of two genes encoding the pheromone

Dominant-negative mutants of a yeast G-protein beta subunit identify two functional regions involved in pheromone signalling

A fungal mating type protein that regulates sexual and asexual development contains a POU-related domain

The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components

The ras1 function of Schizosaccharomyces pombe mediates pheromone-induced transcription

1991

"The maternally expressed Drosophila gene encoding the chromatin-binding protein BJ1 is a homolog of the vertebrate gene Regulator of Chromatin Condensation, RCC1"

Mutation of the hamster cell cycle gene RCC1 is complemented by the homologous genes of Drosophila and S.cerevisiae

The DNA binding and oligomerization domain of MCM1 is sufficient for its interaction with other regulatory proteins

Tyrosine phosphorylation of a yeast 40 kDa protein occurs in response to mating pheromone

Saccharomyces cerevisiae a- and alpha-agglutinin: characterization of their molecular interaction

The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins

The Schizosaccharomyces pombe mam2 gene encodes a putative pheromone receptor which has a significant homology with the Saccharomyces cerevisiae Ste2 protein

1990

Cotranslational glycosylation of proteins in systems depleted of protein disulphide isomerase

The pat1 protein kinase controls transcription of the mating-type genes in fission yeast

Regulation of the yeast pheromone response pathway by G protein subunits

1989

Characterization of the END1 gene required for vacuole biogenesis and gluconeogenic growth of budding yeast

Functional compartments of the yeast Golgi apparatus are defined by the sec7 mutation

Mapping the double-strand breaks at the mating-type locus in fission yeast by genomic sequencing

Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells

1988

Four mating-type genes control sexual differentiation in the fission yeast

"Interactions of purified transcription factors: binding of yeast MAT alpha 1 and PRTF to cell type-specific, upstream activating sequences"

Secretion in yeast: in vitro analysis of the sec53 mutant

The WHI1+ gene of Saccharomyces cerevisiae tethers cell division to cell size and is a cyclin homolog

Purification and characterization of the inducible a agglutinin of Saccharomyces cerevisiae

Post-translational transport of proteins into microsomal membranes of Candida maltosa

1987

Common signal transduction system shared by STE2 and STE3 in haploid cells of Saccharomyces cerevisiae: autocrine cell-cycle arrest results from forced expression of STE2

"The product of the mei3+ gene, expressed under control of the mating-type locus, induces meiosis and sporulation in fission yeast"

Secretion in yeast: structural features influencing the post-translational translocation of prepro-alpha-factor in vitro

1986

Mating pheromone-like diffusible factor released by Schizosaccharomyces pombe

Expression of murine and human granulocyte-macrophage colony-stimulating factors in S. cerevisiae: mutagenesis of the potential glycosylation sites

Secretion in yeast: translocation and glycosylation of prepro-alpha-factor in vitro can occur via an ATP-dependent post-translational mechanism

1985

Hormone processing and membrane-bound proteinases in yeast

The B chain of PDGF alone is sufficient for mitogenesis

1984

Characterization of two genes required for the position-effect control of yeast mating-type genes

The yeast MATa1 gene contains two introns