2021

Early behavioral and molecular events leading to caste switching in the ant Harpegnathos

Genetic basis of chemical communication in eusocial insects

2017

Dendritic Eph organizes dendrodendritic segregation in discrete olfactory map formation in Drosophila

2016

Spatial focalization of pheromone/MAPK signaling triggers commitment to cell-cell fusion

2012

A mechanism for the coordination of proliferation and differentiation by spatial regulation of Fus2p in budding yeast

2010

The homeodomain protein hmbx-1 maintains asymmetric gene expression in adult C. elegans olfactory neurons

2009

The rate of cell growth is governed by cell cycle stage

2006

"Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain"

2005

Developmentally induced changes in transcriptional program alter spatial organization across chromosomes

2004

"The induction of sexual development and virulence in the smut fungus Ustilago maydis depends on Crk1, a novel MAPK protein"

2003

daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway

2002

The DAF-7 TGF-beta signaling pathway regulates chemosensory receptor gene expression in C. elegans

Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval induction

The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans

2000

Novel gene expressed in nasal region influences outgrowth of olfactory axons and migration of luteinizing hormone-releasing hormone (LHRH) neurons

Yeast heterochromatin is a dynamic structure that requires silencers continuously

1999

A specific protein-protein interaction accounts for the in vivo substrate selectivity of Ptp3 towards the Fus3 MAP kinase

Nuclear export of Far1p in response to pheromones requires the export receptor Msn5p/Ste21p

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

Somatic pairing of homologs in budding yeast: existence and modulation

1998

The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae

Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gbetagamma complex underlies activation of the yeast pheromone response pathway

"Chromatin assembly factor I contributes to the maintenance, but not the re-establishment, of silencing at the yeast silent mating loci"

1997

Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast

Novel Cdc42-binding proteins Gic1 and Gic2 control cell polarity in yeast

Differential regulation of FUS3 MAP kinase by tyrosine-specific phosphatases PTP2/PTP3 and dual-specificity phosphatase MSG5 in Saccharomyces cerevisiae

"Tcn1p/Crz1p, a calcineurin-dependent transcription factor that differentially regulates gene expression in Saccharomyces cerevisiae"

The Cdc42 GTPase-associated proteins Gic1 and Gic2 are required for polarized cell growth in Saccharomyces cerevisiae

1996

Purification and characterization of an extracellular peptide factor that affects two different developmental pathways in Bacillus subtilis

"Selection of axial growth sites in yeast requires Axl2p, a novel plasma membrane glycoprotein"

Two novel targets of the MAP kinase Kss1 are negative regulators of invasive growth in the yeast Saccharomyces cerevisiae

Silencers are required for inheritance of the repressed state in yeast

The Saccharomyces retrotransposon Ty5 integrates preferentially into regions of silent chromatin at the telomeres and mating loci

1995

Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast

Convergent sensing pathways mediate response to two extracellular competence factors in Bacillus subtilis

MATa donor preference in yeast mating-type switching: activation of a large chromosomal region for recombination

"Mutation of RGA1, which encodes a putative GTPase-activating protein for the polarity-establishment protein Cdc42p, activates the pheromone-response pathway in the yeast Saccharomyces cerevisiae"

1994

"Identification of fuz7, a Ustilago maydis MEK/MAPKK homolog required for a-locus-dependent and -independent steps in the fungal life cycle"

"The global transcriptional regulators, SSN6 and TUP1, play distinct roles in the establishment of a repressive chromatin structure"

Mutation of the SPS1-encoded protein kinase of Saccharomyces cerevisiae leads to defects in transcription and morphology during spore formation

Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein

"The fission yeast mating pheromone P-factor: its molecular structure, gene structure, and ability to induce gene expression and G1 arrest in the mating partner"

The MAP kinase Fus3 associates with and phosphorylates the upstream signaling component Ste5

G1 cyclins CLN1 and CLN2 repress the mating factor response pathway at Start in the yeast cell cycle

Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: mating and invasive growth

1993

Coupling of cell identity to signal response in yeast: interaction between the alpha 1 and STE12 proteins

Negative regulation of FAR1 at the Start of the yeast cell cycle

1992

Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein

Mutations affecting stability and deadenylation of the yeast MFA2 transcript

Direct induction of G1-specific transcripts following reactivation of the Cdc28 kinase in the absence of de novo protein synthesis

Signal transduction in Saccharomyces cerevisiae requires tyrosine and threonine phosphorylation of FUS3 and KSS1

3'-UTR-dependent deadenylation by the yeast poly(A) nuclease

"The combination of dissimilar alleles of the A alpha and A beta gene complexes, whose proteins contain homeo domain motifs, determines sexual development in the mushroom Coprinus cinereus"

Order of action of components in the yeast pheromone response pathway revealed with a dominant allele of the STE11 kinase and the multiple phosphorylation of the STE7 kinase

1991

"The carboxyl terminus of Scg1, the G alpha subunit involved in yeast mating, is implicated in interactions with the pheromone receptors"

N-myristoylation is required for function of the pheromone-responsive G alpha protein of yeast: conditional activation of the pheromone response by a temperature-sensitive N-myristoyl transferase

Mutations in the HML E silencer of Saccharomyces cerevisiae yield metastable inheritance of transcriptional repression

Pheromone-dependent phosphorylation of the yeast STE12 protein correlates with transcriptional activation

A new role for MCM1 in yeast: cell cycle regulation of SW15 transcription

RAP1 protein activates and silences transcription of mating-type genes in yeast

Mutations in the guanine nucleotide-binding domains of a yeast G alpha protein confer a constitutive or uninducible state to the pheromone response pathway

MAT alpha 1 can mediate gene activation by a-mating factor

1990

STE11 is a protein kinase required for cell-type-specific transcription and signal transduction in yeast

The b mating-type locus of Ustilago maydis contains variable and constant regions

Overproduction of the yeast STE12 protein leads to constitutive transcriptional induction

1989

"The yeast transcription activator PRTF, a homolog of the mammalian serum response factor, is encoded by the MCM1 gene"

A protein involved in minichromosome maintenance in yeast binds a transcriptional enhancer conserved in eukaryotes

"STE12, a protein involved in cell-type-specific transcription and signal transduction in yeast, is part of protein-DNA complexes"

1988

"Flexibility of the yeast alpha 2 repressor enables it to occupy the ends of its operator, leaving the center free"

The human c-fos serum response factor and the yeast factors GRM/PRTF have related DNA-binding specificities

Structure and expression of a Drosophila male accessory gland gene whose product resembles a peptide pheromone precursor

1987

The mother-daughter mating type switching asymmetry of budding yeast is not conferred by the segregation of parental HO gene DNA strands