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Rev Mal Respir

Title:		[Non-allergenic impact of indoor mold exposure]
Author(s):		Gautier C; Caillaud D; Charpin D;
Address:		"Clinique des bronches, allergie et sommeil, hopital Nord, chemin des Bourrelly, 13015 Marseille, France. Hopital Montpied, CHU de Clermont-Ferrand, 63003 Clermont-Ferrand cedex 1, France. Clinique des bronches, allergie et sommeil, hopital Nord, chemin des Bourrelly, 13015 Marseille, France; Inserm U 1067, Aix-Marseille universite et association pour la prevention de la pollution atmospherique, 13284 Marseille, France. Electronic address: denis-andre.charpin@ap-hm.fr"
Journal Title:		Rev Mal Respir
Year:		2018
Volume:		20180705
Issue:		6
Page Number:		652 - 658
DOI:		10.1016/j.rmr.2018.05.012
ISSN/ISBN:		1776-2588 (Electronic) 0761-8425 (Linking)
Abstract:		"The proportion of moldy housing in France is around 20%. It is not simple to establish that a health impact of mold is not allergic, because the identification of allergy is itself difficult. Moreover, exposure to molds and their metabolites may have a protective effect. Non-allergic health impacts may occur due to the multiple aerocontaminants found in damp or mold-containing dwellings: glucans, microbial volatile organic compounds, mycotoxins, bacteria and endotoxins. The heath impacts of indoor mold have been addressed by numerous toxicologic and epidemiologic investigations, the results of which have been summarized in three notable reports. These conclude that mold exposure is linked to a risk of ENT and bronchial symptoms, both the genesis and exacerbation of asthma and, lastly, hypersensitivity pneumonitis. Finally, other studies highlight the protective role of fungal metabolites with respect to asthma and allergy. Pulmonologists should be aware of these data, which can be useful in clinical practice and also in legal work"
Keywords:		"*Air Microbiology Air Pollution, Indoor/*adverse effects/statistics & numerical data Asthma/etiology *Environmental Exposure/adverse effects France/epidemiology Fungi/*physiology Housing/statistics & numerical data Humans Mycotoxins/metabolism Volatile Or;"
Notes:		"MedlineGautier, C Caillaud, D Charpin, D fre Review France 2018/07/10 Rev Mal Respir. 2018 Jun; 35(6):652-658. doi: 10.1016/j.rmr.2018.05.012. Epub 2018 Jul 5"