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Mol Cell Biol

Title:		Striking similarities between the regulatory mechanisms governing yeast mating-type genes and mammalian major histocompatibility complex genes
Author(s):		Weissman JD; Singer DS;
Address:		"Experimental Immunology Branch, National Cancer Institute, Bethesda, Maryland 20892"
Journal Title:		Mol Cell Biol
Year:		1991
Volume:		11
Issue:		8
Page Number:		4228 - 4234
DOI:		10.1128/mcb.11.8.4228-4234.1991
ISSN/ISBN:		0270-7306 (Print) 1098-5549 (Electronic) 0270-7306 (Linking)
Abstract:		"Expression of a mammalian major histocompatibility complex (MHC) class I gene is in part regulated by a silencer DNA sequence element which binds a complex of silencer factors. This negative regulatory system is shown to be strikingly similar to the yeast alpha 2 mating-type repression system. A moderate DNA sequence homology exists between the MHC class I silencer DNA element and the yeast alpha 2 operator. Mammalian silencer factors specifically bind to the yeast alpha 2 operator DNA and also specifically interact with a yeast alpha 2-binding protein. Furthermore, the alpha 2 operator functions as a silencer element in mammalian cells when placed upstream of a MHC class I promoter"
Keywords:		"Animals Base Sequence Cell Line *Genes, Fungal *Genes, Mating Type, Fungal *Genes, Regulator *Major Histocompatibility Complex Mating Factor Models, Genetic Molecular Sequence Data Oligonucleotide Probes Peptides/*genetics Pheromones/genetics Saccharomyce;"
Notes:		"MedlineWeissman, J D Singer, D S eng Comparative Study 1991/08/01 Mol Cell Biol. 1991 Aug; 11(8):4228-34. doi: 10.1128/mcb.11.8.4228-4234.1991"