| Title: | Rapid Screening of Trace Volatile and Nonvolatile Illegal Drugs by Miniature Ion Trap Mass Spectrometry: Synchronized Flash-Thermal-Desorption Purging and Ion Injection |
| Author(s): | Wang W; Wang S; Xu C; Li H; Xing Y; Hou K; Li H; |
| Address: | "Key Laboratory of Separation Science for Analytical Chemistry , Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS) , 457 Zhongshan Road , Dalian 116023 , People's Republic of China. University of Chinese Academy of Sciences , 19 Yuquan Road , Beijing 100049 , People's Republic of China. Yunnan Police Officer Academy , 249 Jiaochang North Road , Kunming 650223 , China" |
| DOI: | 10.1021/acs.analchem.9b02309 |
| ISSN/ISBN: | 1520-6882 (Electronic) 0003-2700 (Linking) |
| Abstract: | "The increasing demand for rapid and sensitive roadside identification of trace illegal drugs drives the development of high-performance miniature mass spectrometric instrumentation and methodology. Here, we report a synchronized flash-thermal-desorption purging and ion injection (SFTDPI) method to increase the sensitive and rapid screening of volatile and nonvolatile illegal drugs for miniature ion trap mass spectrometry (ITMS). The flash-thermal desorption could reach 290 degrees C in 2.5 s, which could achieve efficient vaporization of nonvolatile noscapine with boiling point at 565 degrees C. ITMS using discontinuous atmospheric pressure interface (DAPI) has an ion utilization ratio of less than 1%, the synchronized purging for flash-thermal desorption and ion injection with DAPI could accurately control the time interval along with the desorption, gas purging, ionization and ion injection, and the sample utilization ratio increases more than five times. The miniature SFTDPI-ITMS presents good performance: (1) more than 60 times improvement in sensitivity was achieved compared to the previously reported thermal-desorption acetone-assisted photoionization ion trap mass spectrometer for nonvolatile drugs, and the minimum detectable quantity reaches 50 pg for fentanyl. (2) Ten kinds of mixing drugs with boiling point difference of 300 degrees C can be simultaneously identified within 3 s under a single analysis. SFTDPI-ITMS was deployed at the roadside checkpoint of Sino-Burmese border; fentanyl in the captured encapsulated powder and the suspected opiate had been successfully identified" |
| Keywords: | "High-Throughput Screening Assays/*methods Illicit Drugs/*analysis Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/*instrumentation/*methods Volatile Organic Compounds/*analysis;" |
| Notes: | "MedlineWang, Weimin Wang, Shuang Xu, Chuting Li, Hong Xing, Yuming Hou, Keyong Li, Haiyang eng Research Support, Non-U.S. Gov't 2019/07/18 Anal Chem. 2019 Aug 6; 91(15):10212-10220. doi: 10.1021/acs.analchem.9b02309. Epub 2019 Jul 26" |
