| Title: | Profiles of Volatile Biomarkers Detect Tuberculosis from Skin |
| Author(s): | Vishinkin R; Busool R; Mansour E; Fish F; Esmail A; Kumar P; Gharaa A; Cancilla JC; Torrecilla JS; Skenders G; Leja M; Dheda K; Singh S; Haick H; |
| Address: | "Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa, 3200003, Israel. Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine and UCT Lung Institute & South African MRC/UCT Centre for the Study of Antimicrobial Resistance, University of Cape Town, Cape Town 7925, South Africa. All India Institute of Medical Sciences, New Delhi, 110029, India. The Scintillon Institute, San Diego, CA, 92121, USA. Department of Chemical and Materials Engineering, Complutense University of Madrid, Madrid, 28040, Spain. Institute of Clinical and Preventive Medicine, University of Latvia and Riga east University Hospital, Riga, LV1079, Latvia. Faculty of Infectious and Tropical Diseases, Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK" |
| ISSN/ISBN: | 2198-3844 (Electronic) 2198-3844 (Linking) |
| Abstract: | "Tuberculosis (TB) is an infectious disease that threatens >10 million people annually. Despite advances in TB diagnostics, patients continue to receive an insufficient diagnosis as TB symptoms are not specific. Many existing biodiagnostic tests are slow, have low clinical performance, and can be unsuitable for resource-limited settings. According to the World Health Organization (WHO), a rapid, sputum-free, and cost-effective triage test for real-time detection of TB is urgently needed. This article reports on a new diagnostic pathway enabling a noninvasive, fast, and highly accurate way of detecting TB. The approach relies on TB-specific volatile organic compounds (VOCs) that are detected and quantified from the skin headspace. A specifically designed nanomaterial-based sensors array translates these findings into a point-of-care diagnosis by discriminating between active pulmonary TB patients and controls with sensitivity above 90%. This fulfills the WHO's triage test requirements and poses the potential to become a TB triage test" |
| Keywords: | Adult Biomarkers/metabolism Female Gas Chromatography-Mass Spectrometry Humans India Male Middle Aged Reproducibility of Results Sensitivity and Specificity Skin/*metabolism South Africa Tuberculosis/*diagnosis/*metabolism Volatile Organic Compounds/*meta; |
| Notes: | "MedlineVishinkin, Rotem Busool, Rami Mansour, Elias Fish, Falk Esmail, Ali Kumar, Parveen Gharaa, Alaa Cancilla, John C Torrecilla, Jose S Skenders, Girts Leja, Marcis Dheda, Keertan Singh, Sarman Haick, Hossam eng Ariane de Rothschild Foundation/ 824270/H2020 Industrial Leadership/ OPP1109493/Bill and Melinda Gates Foundation/ Multicenter Study Research Support, Non-U.S. Gov't Germany 2021/06/03 Adv Sci (Weinh). 2021 Aug; 8(15):e2100235. doi: 10.1002/advs.202100235. Epub 2021 Jun 2" |
