| Title: | An RNA binding protein negatively controlling differentiation in fission yeast |
| Author(s): | Tsukahara K; Yamamoto H; Okayama H; |
| Address: | "Department of Biochemistry and Molecular Biology, The University of Tokyo Graduate School of Medicine, Bunkyo-ku, Tokyo 113, Japan" |
| ISSN/ISBN: | 0270-7306 (Print) 1098-5549 (Electronic) 0270-7306 (Linking) |
| Abstract: | "The fission yeast Schizosaccharomyces pombe starts sexual development when starved for nutrients and simultaneously activated by mating pheromones. We have identified a new gene regulating the onset of this process. This gene, called nrd1(+), encodes a typical RNA binding protein that preferentially binds poly(U). Deletion of nrd1(+) causes cells to initiate sexual development without nutrient starvation. We have found that the biological role of nrd1(+) is to block the onset of sexual development by repressing the Ste11-regulated genes essential for conjugation and meiosis until cells reach a critical level of starvation" |
| Keywords: | "Amino Acid Sequence Base Sequence Binding Sites Calcium-Calmodulin-Dependent Protein Kinases/metabolism Carrier Proteins/metabolism Cell Differentiation Culture Media DNA, Fungal Fungal Proteins/genetics/*metabolism Gene Deletion Genes, Fungal Humans *Int;" |
| Notes: | "MedlineTsukahara, K Yamamoto, H Okayama, H eng Research Support, Non-U.S. Gov't 1998/07/22 Mol Cell Biol. 1998 Aug; 18(8):4488-98. doi: 10.1128/MCB.18.8.4488" |
