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Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi

Title:		[Study on the genetic damage in mice induced by the volatile organic compounds of decoration materials]
Author(s):		Tao XY; Yu SY; Kang L; Huang HX; Wei AY;
Address:		"Shenzhen Institute of Health Inspection, Shenzhen 518020, China"
Journal Title:		Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
Year:		2004
Volume:		22
Issue:		3
Page Number:		194 - 196
DOI:
ISSN/ISBN:		1001-9391 (Print) 1001-9391 (Linking)
Abstract:		"OBJECTIVE: To study genetic damage of mice caused by the volatile organic compounds (VOC) of decoration materials. METHODS: Fifty-five hotel guest rooms newly decorated within 6 months and 18 hotel guest rooms not decorated within 3 years were selected to determine the concentrations of 6 main VOC (benzene, methylbenzene, dimethylbenzene, ethyl acetate, butyl acetate, formaldehyde) in the air. Mice were exposed to VOC with the concentrations of 5, 10, 20, 40 times respectively as high as those present in the newly decorated rooms in an exposure cabinet for 15 days. DNA damage of peripheral lymphocytes of the mice was determined by single cell gel electrophoresis (SCGE) and bone marrow micronucleus test. RESULTS: The concentrations of benzene, methylbenzene, dimethylbenzene, ethyl acetate, butyl acetate and formaldehyde in the rooms newly decorated within 6 months (6.50, 3.00, 6.70, 41.33, 1.70 and 0.14 mg/m(3) respectively) were significantly higher than those in rooms not decorated within 3 years (0.08, 0.94, 1.38, 0.25, 0.25, 0.01 mg/m(3), P < 0.01). DNA damage rates of peripheral lymphocytes in the concentrations of 10, 20, 40 times of exposure groups were significantly higher than those in the control groups (P < 0.05 or P < 0.01), and the frequencies of micronucleus in the mice exposed to 40 times of concentration was significantly higher than that in control group. CONCLUSION: High concentrations of the volatile organic chemical compounds may cause genetic damage in mice. SCGE test is more sensitive than micronucleus test"
Keywords:		"Air Pollutants/*toxicity Air Pollution, Indoor/adverse effects Animals DNA Damage/*drug effects Mice Micronucleus Tests No-Observed-Adverse-Effect Level Organic Chemicals/*toxicity Paint/*adverse effects;"
Notes:		"MedlineTao, Xiao-yan Yu, Shu-yuan Kang, Li Huang, Hai-xiong Wei, An-ye chi English Abstract China 2004/07/17 Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2004 Jun; 22(3):194-6"