| Title: | Rapid Diagnosis of Urinary Tract Cancers on a LEGO-Inspired Detection Platform via Chemiresistive Profiling of Volatile Metabolites |
| Author(s): | Sun L; Liu X; Liu S; Chen X; Li Z; |
| Address: | "Institute for Advanced Study, Shenzhen University, 3688 Nanhai Road, Shenzhen, Guangdong 518060, P. R. China. Department of Chemistry, Xinxiang Medical University, 601 Jinsui Road, Xinxiang, Henan 453003, P. R. China" |
| DOI: | 10.1021/acs.analchem.3c03252 |
| ISSN/ISBN: | 1520-6882 (Electronic) 0003-2700 (Linking) |
| Abstract: | "Rapid and in situ profiling of volatile metabolites from body fluids represents a new trend in cancer diagnosis and classification in the early stages. We report herein an on-chip strategy that combines an array of conductive nanosensors with a chaotic gas micromixer for real-time monitoring of volatiles from urine and for accurate diagnosis and classification of urinary tract cancers. By integrating a class of LEGO-inspired microchambers immobilized with MXene-based sensing nanofilms and zigzag microfluidic gas channels, it enables the intensive intermingling of volatile organic chemicals with sensor elements that tremendously facilitate their ion-dipole interactions for molecular recognition. Aided with an all-in-one, point-of-care platform and an effective machine-learning algorithm, healthy or diseased samples from subpopulations (i.e., tumor subtypes, staging, lymph node metastasis, and distant metastasis) of urinary tract cancers can be reliably fingerprinted in a few minutes with high sensitivity and specificity. The developed detection platform has proven to be a noninvasive supplement to the liquid biopsies available for facile screening of urinary tract cancers, which holds great potential for large-scale personalized healthcare in low-resource areas" |
| Keywords: | Humans *Volatile Organic Compounds *Urologic Neoplasms *Body Fluids Oligonucleotide Array Sequence Analysis; |
| Notes: | "MedlineSun, Linlin Liu, Xueliang Liu, Sihui Chen, Xiaofeng Li, Zheng eng 2023/09/22 Anal Chem. 2023 Oct 3; 95(39):14822-14829. doi: 10.1021/acs.analchem.3c03252. Epub 2023 Sep 22" |
