| Title: | "Pseudotsuga menziesii (Pinaceae): Volatile Profiles, Antimicrobial Activity and Toxicological Evaluation of Its Essential Oil" |
| Author(s): | Mitic ZS; Stojanovic-Radic Z; Cvetkovic VJ; Jovanovic SC; Dimitrijevic M; Ickovski JD; Jovanovic N; Mihajilov-Krstev T; Stojanovic GS; |
| Address: | "Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Nis, Visegradska 33, 18000, Nis, Serbia. Department of Chemistry, Faculty of Sciences and Mathematics, University of Nis, Visegradska 33, 18000, Nis, Serbia" |
| ISSN/ISBN: | 1612-1880 (Electronic) 1612-1872 (Linking) |
| Abstract: | "The present article investigates the chemical composition of volatiles of essential oil (EO) and headspace (HS) fraction, as well as biological activities of EO obtained from needles with twigs of Pseudotsuga menziesii var. menziesii cultivated in Serbia. The major class of compounds was monoterpene hydrocarbons with alpha-terpinolene, sabinene and beta-pinene (EO), and sabinene, alpha-terpinolene and beta-pinene (HS) as the dominant volatiles. Tested EO exhibited mostly low antimicrobial potential against investigated strains (ATCC and respiratory isolates), where MICs ranged 1.25-20.00 mg/mL. Nevertheless, based on presented results, where antimicrobial testing was done for the first time on human respiratory system isolates, there is a potential of this EO to be used as an adjuvant in the treatment of human respiratory infections, especially those caused by Pseudomonas aeruginosa or Candida albicans strains. Regarding toxicological evaluation, EO showed moderate toxicity in Artemia salina toxicity bioassay (LC(50) =347.41, after 24 h) as well as week toxicity against Drosophila melanogaster with the ability only to moderately delay larval and pupal development" |
| Keywords: | Animals Anti-Bacterial Agents/chemistry/isolation & purification/*pharmacology Antifungal Agents/chemistry/isolation & purification/*pharmacology Artemia/drug effects Candida albicans/drug effects Drosophila melanogaster/drug effects Humans Microbial Sens; |
| Notes: | "MedlineMitic, Zorica S Stojanovic-Radic, Zorica Cvetkovic, Vladimir J Jovanovic, Snezana C Dimitrijevic, Marina Ickovski, Jovana D Jovanovic, Nikola Mihajilov-Krstev, Tatjana Stojanovic, Gordana S eng 451-03-68/2020-14/200124/Ministry of Education, Science and Technological Development of the Republic of Serbia/ Switzerland 2021/07/04 Chem Biodivers. 2021 Sep; 18(9):e2100424. doi: 10.1002/cbdv.202100424. Epub 2021 Jul 16" |
