| Title: | Preconcentration and analysis of trace volatile carbonyl compounds |
| Author(s): | Li M; Biswas S; Nantz MH; Higashi RM; Fu XA; |
| Address: | "Department of Chemical Engineering, University of Louisville, Louisville, Kentucky 40292, USA" |
| ISSN/ISBN: | 1520-6882 (Electronic) 0003-2700 (Linking) |
| Abstract: | "We describe a preconcentration device that may be suitable for quantitative analysis of trace volatile ketones and aldehydes in ambient air as well as in human breath. The approach is based on microreactor chips fabricated from silicon wafers. The microreactors have thousands of micropillars in microfluidic channels for uniformly distributing a gaseous sample flowing through the chips. The surfaces of the micropillars are functionalized with a quaternary ammonium aminooxy salt, [2-(aminooxy)ethyl]-N,N,N-trimethylammonium iodide (ATM), for trapping trace ketones and aldehydes by means of oximation reactions. ATM adducts and unreacted ATM are eluted from the microreactor with less than 40 muL of methanol and directly analyzed by nanospray Fourier transform ion cyclotron resonance (FTICR) mass spectrometry (MS). Ketones and aldehydes at levels of 1 ppbv have been detected using this microreactor and FTICR-MS system" |
| Keywords: | "Air/analysis Aldehydes/*analysis Humans Ketones/*analysis Methanol/chemistry Microfluidic Analytical Techniques Quaternary Ammonium Compounds/chemistry *Spectrometry, Mass, Electrospray Ionization Surface Properties Volatile Organic Compounds/*analysis;" |
| Notes: | "MedlineLi, Mingxiao Biswas, Souvik Nantz, Michael H Higashi, Richard M Fu, Xiao-An eng Research Support, Non-U.S. Gov't 2011/12/08 Anal Chem. 2012 Feb 7; 84(3):1288-93. doi: 10.1021/ac2021757. Epub 2012 Jan 20" |
