| Title: | [Research on volatile components of gualou guizhi decoction and its components in rat brain by GC-MS] |
| Author(s): | Li H; Xu W; Xu W; Zhang YQ; Chu KD; Chen LD; Chen XW; |
| Journal Title: | Zhongguo Zhong Yao Za Zhi |
| ISSN/ISBN: | 1001-5302 (Print) 1001-5302 (Linking) |
| Abstract: | "To investigate the role of volatile components in the compound and to find the substance foundation of Gualou Guizhi decoction (GLGZD) for curing extremities spasticity after stroke. The chemical compositions of essential oil, obtained by hydrodistillation from Gualou Guizhi decoction and its major constituting herbs (Trichosanthis Radix, Paeoniae Alba Radix, Cinnamomi Ramulus, Zingiberis Recens Rhizoma, Glycyrrhizae Radix, Ziziphi Jujubae Fructus) were analyzed by GC-MS to evaluate the correlativity between volatile components of GLGZD and its major constituting herbs, and volatile components after oral administration of GLGZD in the rats' brain. Volatile components of GLGZD are mainly derived from Cinnamomi Ramulus, Zingiberis Recens Rhizoma, Ziziphi Jujubae Fructus, Trichosanthis Radix. The volatile components in the brain is mostly derived from radix trichosanthis. Compared with individual herbs of GLGZD, the dissolution of the components increase or new components appear after compatibility of six herbs. Adminstrated with GLGZD, the results point out that volatile components in the brain play a neuroprotective role through passing the brain" |
| Keywords: | "Animals Brain/*drug effects Drugs, Chinese Herbal/*chemistry/*pharmacology Gas Chromatography-Mass Spectrometry Male Rats Rats, Sprague-Dawley Volatile Organic Compounds/*chemistry/*pharmacology;" |
| Notes: | "MedlineLi, Huang Xu, Wen Xu, Wei Zhang, Yu-Qin Chu, Ke-Dan Chen, Li-Dian Chen, Xian-Wen chi English Abstract Research Support, Non-U.S. Gov't China 2014/07/22 Zhongguo Zhong Yao Za Zhi. 2014 Apr; 39(8):1509-15" |
