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Annu Rev Entomol

Title:		Serotonin modulation of moth central olfactory neurons
Author(s):		Kloppenburg P; Mercer AR;
Address:		"Institute of Zoology, University of Cologne, Cologne, Germany. peter.kloppenburg@uni-koeln.de"
Journal Title:		Annu Rev Entomol
Year:		2008
Volume:		53
Issue:
Page Number:		179 - 190
DOI:		10.1146/annurev.ento.53.103106.093408
ISSN/ISBN:		0066-4170 (Print) 0066-4170 (Linking)
Abstract:		"In the tobacco hornworm, Manduca sexta, 5-hydroxytryptamine (5HT) acting at the level of the antennal lobes contributes significantly to changing the moth's responsiveness to olfactory stimuli. 5HT targets K(+) conductances in the cells, increasing the excitability of central olfactory neurons and their responsiveness to olfactory cues. Effects of 5HT modulation are apparent not only at the single cell level, but also in the activity patterns of populations of neurons that convey olfactory information from antennal lobes to higher centers of the brain. Evidence suggests that 5HT-induced changes in activity within neural circuits of the antennal lobes might also drive structural plasticity, providing the basis for longer-term changes in antennal lobe function"
Keywords:		Animals Brain/physiology Female Male Manduca/metabolism/*physiology Neurons/physiology Olfactory Nerve/drug effects/*physiology Serotonin/immunology/*metabolism/pharmacology Serotonin Agents/immunology/pharmacology Sex Attractants/physiology;
Notes:		"MedlineKloppenburg, Peter Mercer, Alison R eng Review 2007/12/11 Annu Rev Entomol. 2008; 53:179-90. doi: 10.1146/annurev.ento.53.103106.093408"