| Title: | Synaptic mechanisms underlying pheromonal memory in vomeronasal system |
| Address: | "Laboratory of Cell Biology and Anatomy, Department of Basic Techniques and Facilities, Tokyo Metropolitan Institute for Neuroscience. mich@tmin.ac.jp" |
| ISSN/ISBN: | 0289-0003 (Print) 0289-0003 (Linking) |
| Abstract: | "When female mice are mated, they form a memory of the pheromonal signal of the male with which they mated. Our research objective was to determine the neural mechanisms underlying learning and memory by employing a convenient model of pheromone-induced olfactory memory (pheromonal memory). Formation of pheromonal memory depends on the association between mating and exposure to pheromones. Synaptic plasticity involving this memory occurs in the accessory olfactory bulb (AOB), depending on vaginocervical stimulation at mating. The vaginocervical stimulation at mating reduces the dendrodendritic feedback inhibition of principal neurons (mitral/tufted (MT) cells) in the AOB and enhances their cell activity. The enhancement of activity induces on these plastic changes in dendrodendritic synapses, which in turn enhance GABA-mediated inhibition of MT cell activity. This 'self-inhibition' of MT cells activity in response to pheromonal signals of the partner can disrupt its signals at the AOB thereby preventing the signals from reaching the central brain. The formation and maintenance of pheromonal memory is based on this inhibition mechanism" |
| Keywords: | "Animals Female Male Mice Neuronal Plasticity/*physiology Olfactory Bulb/cytology/*physiology Sex Attractants/*pharmacology Sexual Behavior, Animal Vomeronasal Organ/*physiology gamma-Aminobutyric Acid/pharmacology;Neuroscience;" |
| Notes: | "MedlineIchikawa, Masumi eng Review Japan 2003/07/02 Zoolog Sci. 2003 Jun; 20(6):687-95. doi: 10.2108/zsj.20.687" |
