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Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi

Title:		[Toxic effects of mixture of volatile organic compounds on mice testis related enzymes and hormones]
Author(s):		Hao L; He J; Zhang L; Guo J; Qi N; Yang Z; Zhang X; Yang L; Zhang Z;
Address:		"Hangzhou Center for Disease Control and Prevention, Hangzhou 310006, China. E-mail: zhangzengli@suda.edu.cn"
Journal Title:		Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
Year:		2015
Volume:		33
Issue:		9
Page Number:		682 - 684
DOI:
ISSN/ISBN:		1001-9391 (Print) 1001-9391 (Linking)
Abstract:		"OBJECTIVE: To evaluate the toxic effects of mixture of volatile organic compounds (VOCs) on Mice Testis related enzymes and hormones. METHODS: After determining the median lethal dose (LD(5)(0)) of VOCs using the acute toxicity test, 40 male clean inbred Kunming mice were assigned to 1/8 LD(5)(0) VOCs exposure group, 1/4 LD(5)(0) VOCs exposure group, and 1/2 LD(5)(0) VOCs exposure group, as well as positive control group with cyclophosphamide (60 mg/kg) and negative control group with tea oil, with 8 mice in each group. The mice were intraperitoneally injected with respective agents for 5 days. The levels of testis testosterone, estradiol, follicle stimulating hormone, and luteinizing hormone were determined by ELISA. Meanwhile, the activity of testicular marked enzymes such as lactate dehydrogenase, gamma-glutamyl transpeptidase, acid phosphatase, and glucose-6-phosphate dehydrogenase were examined. RESULTS: Compared with the negative control group, the 1/8 LD(5)(0) exposure group had a significantly increased testis coefficient (P<0.05). Both the activity of testicular marked enzymes and the levels of testicular sex hormones in all exposure groups showed significant downward trends with increasing VOC doses compared with those in the negative control group (P<0.05). CONCLUSION: VOCs have obvious toxicity to mouse testis by changing the levels of testicular sex hormones and the activity of testicular marked enzymes"
Keywords:		Animals Estradiol/chemistry Follicle Stimulating Hormone/chemistry Gonadal Steroid Hormones/*chemistry Luteinizing Hormone/chemistry Male Mice Testis/chemistry/*drug effects Testosterone/chemistry Volatile Organic Compounds/*toxicity;
Notes:		"MedlineHao, Li He, Jinjiang Zhang, Lei Guo, Jianfeng Qi, Nana Yang, Zhangping Zhang, Xuhui Yang, Luoxian Zhang, Zengli chi China 2016/02/03 Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2015 Sep; 33(9):682-4"