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J Breath Res

Title:		The ovarian cycle may influence the exhaled volatile organic compound profile analyzed by an electronic nose
Author(s):		Dragonieri S; Quaranta VN; Carratu P; Ranieri T; Resta O;
Address:		"Respiratory Diseases, University of Bari, Italy"
Journal Title:		J Breath Res
Year:		2018
Volume:		20180301
Issue:		2
Page Number:		21002 -
DOI:		10.1088/1752-7163/aa9eed
ISSN/ISBN:		1752-7163 (Electronic) 1752-7155 (Linking)
Abstract:		"INTRODUCTION: We aimed to investigate whether the sex hormone profile during the ovarian cycle in healthy women could affect the volatile organic compound (VOC) profile analyzed by an electronic nose (e-nose). METHODS: We enrolled 21 healthy, never-smoking, regularly menstruating women who were not taking any medications. A series of exhaled breath measurements were performed on all subjects at predefined intervals (days 1-6, 7-12, 13-19, 20-25 and 26-31; day 1 was the first day of menstruation) during their ovarian cycle and analyzed by an e-nose (Cyranose 320). RESULTS: By principal component analysis, significant modifications of the exhaled VOC profile were observed over the cycle for principal component 1 (PC1; p = 0.001). In particular, the PC1 value was significantly higher during the premenstrual period and during menstruation compared with the first third of estrogen phase, mid-cycle and the first third of progestational phase (for all parameters p < 0.05 and p < 0.01, respectively). Subsequent linear discriminant analysis confirmed the above findings. CONCLUSIONS: The ovarian cycle may alter the exhaled VOC pattern and this should be taken into account during serial measurements of these markers in the female population"
Keywords:		Adult Analysis of Variance Biomarkers/analysis Breath Tests Discriminant Analysis *Electronic Nose *Exhalation Female Humans Menstrual Cycle/*physiology Middle Aged Principal Component Analysis Volatile Organic Compounds/*analysis;
Notes:		"MedlineDragonieri, Silvano Quaranta, Vitaliano N Carratu, Pierluigi Ranieri, Teresa Resta, Onofrio eng Research Support, Non-U.S. Gov't England 2017/12/05 J Breath Res. 2018 Mar 1; 12(2):021002. doi: 10.1088/1752-7163/aa9eed"