| Title: | Guanylyl cyclase-G is an alarm pheromone receptor in mice |
| Author(s): | Chao YC; Fleischer J; Yang RB; |
| Address: | "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Department of Animal Physiology, Institute of Biology/Zoology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany joerg.fleischer@zoologie.uni-halle.de rbyang@ibms.sinica.edu.tw. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan joerg.fleischer@zoologie.uni-halle.de rbyang@ibms.sinica.edu.tw. Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Taiwan. Ph.D. Program in Biotechnology Research and Development, College of Pharmacy, Taipei Medical University, Taipei, Taiwan" |
| ISSN/ISBN: | 1460-2075 (Electronic) 0261-4189 (Print) 0261-4189 (Linking) |
| Abstract: | "Many animals respond to threats by releasing alarm pheromones (APs) that warn conspecifics. In mice, detection of the AP 2-sec-butyl-4,5-dihydrothiazole (SBT) is mediated by chemosensory neurons residing in the Grueneberg ganglion (GG) of the anterior nasal region. Although the molecular mechanisms underlying activation of GG neurons by SBT and other substances are still unclear, recent studies have reported an involvement of the transmembrane guanylyl cyclase (GC) subtype GC-G in chemosensory signaling in the GG Here, we show that SBT directly binds with high affinity to the extracellular domain of GC-G and elicits an enhanced enzymatic activity of this protein. In line with this finding, heterologous expression of GC-G renders cells responsive to SBT while activation by SBT was strongly attenuated in GG neurons from GC-G-deficient mice. Consistently, SBT-induced fear-associated behaviors, SBT-evoked elevated blood pressure, and increased serum levels of the stress hormone corticosterone were clearly reduced in GC-G-knockout animals compared to wild-type mice. These observations suggest that GC-G serves as an unusual receptor in GG neurons mediating the detection of the volatile AP substance SBT" |
| Keywords: | "Animals Behavior, Animal/*drug effects Cyclic GMP/*metabolism Ganglia, Sensory/cytology/*physiology Guanylate Cyclase/*physiology Male Membrane Proteins/*physiology Mice Mice, Inbred C57BL Mice, Knockout Neurons/cytology/*physiology Nose/innervation Phero;" |
| Notes: | "MedlineChao, Ying-Chi Fleischer, Joerg Yang, Ruey-Bing eng Research Support, Non-U.S. Gov't England 2017/10/01 EMBO J. 2018 Jan 4; 37(1):39-49. doi: 10.15252/embj.201797155. Epub 2017 Sep 28" |
