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J Chromatogr A

Title:		Processing gas chromatographic data and confidence interval calculation for partition coefficients determined by the phase ratio variation method
Author(s):		Atlan S; Trelea IC; Saint-Eve A; Souchon I; Latrille E;
Address:		"UMR Genie et Microbiologie des Procedes Alimentaires, INRA INA P-G, BP 01, 1 Avenue Lucien Bretigneres, F-78850 Thiverval-Grignon, France"
Journal Title:		J Chromatogr A
Year:		2006
Volume:		20060131
Issue:		1-Feb
Page Number:		146 - 155
DOI:		10.1016/j.chroma.2006.01.055
ISSN/ISBN:		0021-9673 (Print) 0021-9673 (Linking)
Abstract:		"The phase ratio variation (PRV) method is widely used for the determination of partition coefficient values (dimensionless Henry's law constants) by headspace gas chromatography. Traditional data processing by linear regression has several drawbacks: potential bias introduced by linearization, absence of quality indicator of the resulting value and, in case of replicate determinations, poor utilisation of the existing measurements leading to unnecessarily large confidence intervals. The paper compares existing PRV data processing methods (linear and nonlinear regression, parametric) and derives confidence intervals for the resulting partition coefficient values. The possibility of using several series of measurements to derive a single partition coefficient value with tighter and more reliable confidence intervals is presented for all three processing methods. The methods are tested on published literature data and new experimental data for 12 volatile organic compounds in water at 25 degrees C. The nonlinear regression based on several series of measurements appears to be the method of choice"
Keywords:		"Chromatography, Gas/*methods *Confidence Intervals Mathematics Organic Chemicals/*chemistry Pharmaceutical Preparations/*analysis Regression Analysis Solubility Temperature Volatilization;"
Notes:		"MedlineAtlan, Samuel Trelea, Ioan Cristian Saint-Eve, Anne Souchon, Isabelle Latrille, Eric eng Comparative Study Research Support, Non-U.S. Gov't Netherlands 2006/02/03 J Chromatogr A. 2006 Mar 31; 1110(1-2):146-55. doi: 10.1016/j.chroma.2006.01.055. Epub 2006 Jan 31"