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Cancers (Basel)

Title:		Are Volatile Organic Compounds Accurate Markers in the Assessment of Colorectal Cancer and Inflammatory Bowel Diseases? A Review
Author(s):		Vernia F; Valvano M; Fabiani S; Stefanelli G; Longo S; Viscido A; Latella G;
Address:		"Gastroenterology Unit, Department of Life, Health and Environmental Sciences, University of L'Aquila, Piazza S. Tommasi, Coppito, 67100 L'Aquila, Italy"
Journal Title:		Cancers (Basel)
Year:		2021
Volume:		20210513
Issue:		10
Page Number:		-
DOI:		10.3390/cancers13102361
ISSN/ISBN:		2072-6694 (Print) 2072-6694 (Electronic) 2072-6694 (Linking)
Abstract:		"Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the Western world. Early detection decreases incidence and mortality. Screening programs based on fecal occult blood testing help identify patients requiring endoscopic examination, but accuracy is far from optimal. Among the alternative strategies, volatile organic compounds (VOCs) represent novel potentially useful biomarkers of colorectal cancer. They also represent a promising tool for the screening of both intestinal inflammation and related CRC. The review is focused on the diagnostic potential of VOCs in sporadic CRC and in inflammatory bowel diseases (IBD), which increase the risk of CRC, analyzing future clinical applications. Despite limitations related to inadequate strength of evidence, differing analytical platforms identify different VOCs, and this unconventional approach for diagnosing colorectal cancer is promising. Some VOC profiles, besides identifying inflammation, seem disease-specific in inflammatory bowel diseases. Thus, breath, urine, and fecal VOCs provide a new and promising clinical approach to differential diagnosis, evaluation of the inflammatory status, and possibly the assessment of treatment efficacy in IBD. Conversely, specific VOC patterns correlating inflammatory bowel disease and cancer risk are still lacking, and studies focused on this issue are strongly encouraged. No prospective studies have assessed the risk of CRC development by using VOCs in samples collected before the onset of disease, both in the general population and in patients with IBD"
Keywords:		Crohn's disease Ibd VOCs colorectal cancer inflammatory bowel diseases microbiome ulcerative colitis volatile organic compounds;
Notes:		"PubMed-not-MEDLINEVernia, Filippo Valvano, Marco Fabiani, Stefano Stefanelli, Gianpiero Longo, Salvatore Viscido, Angelo Latella, Giovanni eng Review Switzerland 2021/06/03 Cancers (Basel). 2021 May 13; 13(10):2361. doi: 10.3390/cancers13102361"