| Title: | Divergent seven transmembrane receptors are candidate chemosensory receptors in C. elegans |
| Author(s): | Troemel ER; Chou JH; Dwyer ND; Colbert HA; Bargmann CI; |
| Address: | "Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143-0452, USA" |
| DOI: | 10.1016/0092-8674(95)90162-0 |
| ISSN/ISBN: | 0092-8674 (Print) 0092-8674 (Linking) |
| Abstract: | "Using their senses of taste and smell, animals recognize a wide variety of chemicals. The nematode C. elegans has only fourteen types of chemosensory neurons, but it responds to dozens of chemicals, because each chemosensory neuron detects several stimuli. Here we describe over 40 highly divergent members of the G protein-coupled receptor family that could contribute to this functional diversity. Most of these candidate receptor genes are in clusters of two to nine similar genes. Eleven of fourteen tested genes appear to be expressed in small subsets of chemosensory neurons. A single type of chemosensory neuron can potentially express at least four different receptor genes. Some of these genes might encode receptors for water-soluble attractants, repellents, and pheromones" |
| Keywords: | "1-Octanol Amino Acid Sequence Animals Animals, Genetically Modified Behavior, Animal/drug effects Benzaldehydes/pharmacology Caenorhabditis elegans/*genetics/physiology Chemoreceptor Cells/*physiology Female Gene Expression Genes, Helminth/*genetics Genes;" |
| Notes: | "MedlineTroemel, E R Chou, J H Dwyer, N D Colbert, H A Bargmann, C I eng DC01393/DC/NIDCD NIH HHS/ Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. 1995/10/20 Cell. 1995 Oct 20; 83(2):207-18. doi: 10.1016/0092-8674(95)90162-0" |
