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Int J Environ Res Public Health

Title:		Biomarkers of Exposure to Secondhand and Thirdhand Tobacco Smoke: Recent Advances and Future Perspectives
Author(s):		Torres S; Merino C; Paton B; Correig X; Ramirez N;
Address:		"Department of Electronic Engineering, Universitat Rovira i Virgili, Paisos Catalans 26, 43007 Tarragona, Spain. sonia.torres@urv.cat. Department of Electronic Engineering, Universitat Rovira i Virgili, Paisos Catalans 26, 43007 Tarragona, Spain. carlamelissa.merino@urv.cat. Department of Electronic Engineering, Universitat Rovira i Virgili, Paisos Catalans 26, 43007 Tarragona, Spain. beatrix.paton@urv.cat. Department of Electronic Engineering, Universitat Rovira i Virgili, Paisos Catalans 26, 43007 Tarragona, Spain. xavier.correig@urv.cat. Institut d'Investigacio Sanitaria Pere Virgili, Escorxador s/n, 43003 Tarragona, Spain. xavier.correig@urv.cat. CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Carlos III Health Institute, Monforte de Lemos 3-5, 28029 Madrid, Spain. xavier.correig@urv.cat. Department of Electronic Engineering, Universitat Rovira i Virgili, Paisos Catalans 26, 43007 Tarragona, Spain. noelia.ramirez@urv.cat. Institut d'Investigacio Sanitaria Pere Virgili, Escorxador s/n, 43003 Tarragona, Spain. noelia.ramirez@urv.cat. CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Carlos III Health Institute, Monforte de Lemos 3-5, 28029 Madrid, Spain. noelia.ramirez@urv.cat"
Journal Title:		Int J Environ Res Public Health
Year:		2018
Volume:		20181129
Issue:		12
Page Number:		-
DOI:		10.3390/ijerph15122693
ISSN/ISBN:		1660-4601 (Electronic) 1661-7827 (Print) 1660-4601 (Linking)
Abstract:		"Smoking is the leading preventable disease worldwide and passive smoking is estimated to be the cause of about 1.0% of worldwide mortality. The determination of tobacco smoke biomarkers in human biological matrices is key to assess the health effects related to the exposure to environmental tobacco smoke. The biomonitoring of cotinine, the main nicotine metabolite, in human biofluids-including urine, serum or saliva-has been extensively used to assess this exposure. However, the simultaneous determination of cotinine together with other tobacco biomarkers and the selection of alternative biological matrices, such as hair, skin or exhaled breath, would enable a better characterization of the kind and extent of tobacco exposure. This review aims to perform a critical analysis of the up-to-date literature focused on the simultaneous determination of multiple tobacco smoke biomarkers studied in different biological matrices, due to the exposure to secondhand smoke (SHS) and thirdhand smoke (THS). Target biomarkers included both tobacco-specific biomarkers-nicotine and tobacco specific nitrosamine biomarkers-and tobacco-related biomarkers, such as those from polycyclic aromatic hydrocarbons, volatile organic compounds, metals and carbon monoxide. To conclude, we discuss the suitability of determining multiple biomarkers through several relevant examples of SHS and THS exposure"
Keywords:		"Air Pollution, Indoor/*analysis Biomarkers/*analysis/metabolism Cotinine/*analysis/urine Environmental Monitoring Hair/chemistry Humans Nicotine/*adverse effects/analysis Saliva/chemistry Tobacco/*chemistry/metabolism Tobacco Smoke Pollution/*analysis bio;"
Notes:		"MedlineTorres, Sonia Merino, Carla Paton, Beatrix Correig, Xavier Ramirez, Noelia eng Research Support, Non-U.S. Gov't Review Switzerland 2018/12/07 Int J Environ Res Public Health. 2018 Nov 29; 15(12):2693. doi: 10.3390/ijerph15122693"