| Title: | Exhaled Breath Analysis in Diagnosis of Malignant Pleural Mesothelioma: Systematic Review |
| Author(s): | Toreyin ZN; Ghosh M; Goksel O; Goksel T; Godderis L; |
| Address: | "Department of Public Health and Primary Care, Centre for Environment and Health, University of Leuven (KU Leuven), 3000 Leuven, Belgium. Laboratory of Occupational and Environmental Respiratory Diseases, Division of Immunology, Allergy and Asthma, Department of Pulmonary Medicine, Faculty of Medicine, Ege University, Bornova, 35100 Izmir, Turkey. Department of Pulmonary Medicine, Faculty of Medicine, Ege University, Bornova, 35100 Izmir, Turkey. Idewe, External Service for Prevention and Protection at Work, 3001 Heverlee, Belgium" |
| Journal Title: | Int J Environ Res Public Health |
| ISSN/ISBN: | 1660-4601 (Electronic) 1661-7827 (Print) 1660-4601 (Linking) |
| Abstract: | "Malignant pleural mesothelioma (MPM) is mainly related to previous asbestos exposure. There is still dearth of information on non-invasive biomarkers to detect MPM at early stages. Human studies on exhaled breath biomarkers of cancer and asbestos-related diseases show encouraging results. The aim of this systematic review was to provide an overview on the current knowledge about exhaled breath analysis in MPM diagnosis. A systematic review was conducted on MEDLINE (PubMed), EMBASE and Web of Science databases to identify relevant studies. Quality assessment was done by the Newcastle-Ottawa Scale. Six studies were identified, all of which showed fair quality and explored volatile organic compounds (VOC) based breath profile using Gas Chromatography Coupled to Mass Spectrometry (GC-MS), Ion Mobility Spectrometry Coupled to Multi-capillary Columns (IMS-MCC) or pattern-recognition technologies. Sample sizes varied between 39 and 330. Some compounds (i.e, cyclohexane, P3, P5, P50, P71, diethyl ether, limonene, nonanal, VOC IK 1287) that can be indicative of MPM development in asbestos exposed population were identified with high diagnostic accuracy rates. E-nose studies reported breathprints being able to distinguish MPM from asbestos exposed individuals with high sensitivity and a negative predictive value. Small sample sizes and methodological diversities among studies limit the translation of results into clinical practice. More prospective studies with standardized methodologies should be conducted on larger populations" |
| Keywords: | "*Asbestos *Biomarkers, Tumor/analysis *Breath Tests Exhalation Humans *Mesothelioma/diagnosis Prospective Studies *Volatile Organic Compounds exhaled breath analysis exhaled breath condensate malignant pleural mesothelioma volatile organic compounds;" |
| Notes: | "MedlineToreyin, Zehra Nur Ghosh, Manosij Goksel, Ozlem Goksel, Tuncay Godderis, Lode eng Systematic Review Switzerland 2020/02/14 Int J Environ Res Public Health. 2020 Feb 10; 17(3):1110. doi: 10.3390/ijerph17031110" |
