« Previous AbstractOdorant-Binding Protein HvarOBP5 in Ladybird Hippodamia variegata Regulates the Perception of Semiochemicals from Preys and Habitat Plants    Next AbstractEH domain proteins Pan1p and End3p are components of a complex that plays a dual role in organization of the cortical actin cytoskeleton and endocytosis in Saccharomyces cerevisiae »

Zhongguo Shi Yan Xue Ye Xue Za Zhi

Title:		[Identification of Volatile Organic Compounds Used to Diagnose and Evaluate Acute Promyelocyte Leukemia]
Author(s):		Tang HX; Liu ZQ; Dai JF; Lu Y; Xia HL;
Address:		"Department of Hematology, Chaohu Hospital of Anhui Medical University, Chaohu 238001, Anhui Province, China. Department of Hematology, First Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui Province, China. Medical Physics and Technology Center, Hefei Academy of Physical Sciences, Chinese Academy of Sciences??eHefei 230031, Anhui Province, China. Department of Hematology, Chaohu Hospital of Anhui Medical University, Chaohu 238001, Anhui Province, China??eDepartment of Hematology, First Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui Province, China,E-mail: 1245149378@qq.com"
Journal Title:		Zhongguo Shi Yan Xue Ye Xue Za Zhi
Year:		2020
Volume:		28
Issue:		6
Page Number:		1848 - 1852
DOI:		10.19746/j.cnki.issn.1009-2137.2020.06.010
ISSN/ISBN:		1009-2137 (Print) 1009-2137 (Linking)
Abstract:		"OBJECTIVE: To analyze the characteristics of volatile organic compounds (VOCs) in expiratory air components of patients with acute promyelocytic leukemia (APL), and assess the feasibility of VOCs for the diagnosis and prognostic evaluation of APL. METHODS: The VOCs exhaled from the patients with APL and healthy volunteers should be analyzed with SPME-GC/MS, and compared between newly-diagnosed group, relapse group, remission group, and healthy group with Wilcoxon/Kruskal-Wallis one-way analysis of variance and Dunn-Bonferroni test. RESULTS: Dimethyl sulfide, toluene, and dodecane obtained of newly-diagnosed APL patients were significantly higher, while ethanol, n-hexanal, and benzaldehyde were significantly lower than those of healthy people (P<0.05). Compared with the newly-diagnosed group, dimethylsulfide, toluene, and dodecane of the remission group significantly decreased, while ethanol, n-hexanal, and benzaldehyde significantly increased (P<0.05), which was just opposite from the relapse group. CONCLUSION: Dimethyl sulfide, toluene, dodecane, ethanol, n-hexanal, and benzaldehyde can be used as biomarkers for the diagnosis and prognosis assessment of APL patients"
Keywords:		"Exhalation Gas Chromatography-Mass Spectrometry Granulocyte Precursor Cells Humans *Leukemia, Promyelocytic, Acute/diagnosis *Volatile Organic Compounds/analysis;"
Notes:		"MedlineTang, Hong-Xia Liu, Zhi-Qiang Dai, Ji-Fei Lu, Yan Xia, Hai-Long chi China 2020/12/08 Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020 Dec; 28(6):1848-1852. doi: 10.19746/j.cnki.issn.1009-2137.2020.06.010"