« Previous AbstractEnantiomeric composition of ipsdienol: A chemotaxonomic character for north American populations ofIps spp. in thepini subgeneric group (coleoptera: Scolytidae)    Next AbstractManagement of Western North American Bark Beetles with Semiochemicals »

Annu Rev Entomol

Title:		Biochemistry and molecular biology of de novo isoprenoid pheromone production in the Scolytidae
Author(s):		Seybold SJ; Tittiger C;
Address:		"Department of Entomology, 219 Hodson Hall, 1980 Folwell Avenue, University of Minnesota, St. Paul, Minnesota 55108-6125, USA. sseybold@tc.umn.edu"
Journal Title:		Annu Rev Entomol
Year:		2003
Volume:		20020604
Issue:
Page Number:		425 - 453
DOI:		10.1146/annurev.ento.48.091801.112645
ISSN/ISBN:		0066-4170 (Print) 0066-4170 (Linking)
Abstract:		"Recent application of biochemical and molecular techniques to study the genesis of scolytid aggregation pheromones has revealed that bark beetles are primarily responsible for the endogenous synthesis of widely occurring pheromone components such as ipsenol, ipsdienol, and frontalin. Because many of the chemical signals are isoprenoids, the roles of the mevalonate biosynthetic pathway and the enzyme HMG-CoA reductase (HMG-R) have been investigated. This has led to the identification of endothelial cells in the anterior midgut as the site of synthesis and to the concept that de novo pheromone biosynthesis is regulated in part by the positive effect of juvenile hormone III (JHIII) on gene expression for HMG-R. Both the pronounced regulation by JHIII and the expression pattern of eukaryotic HMG-R argue against synthesis of these pheromones by prokaryotes. As the mevalonate pathway and its regulation have been studied in few other insects, broader issues addressed through the study of scolytid pheromone biosynthesis include major step versus coordinate regulation of the pathway and a genomics approach to elucidating the entire pathway and the mode of action of JHIII"
Keywords:		"Animals Coleoptera/genetics/*metabolism Female Gene Expression Regulation, Enzymologic Genes, Insect Hydroxymethylglutaryl CoA Reductases/genetics In Situ Hybridization Male Models, Biological Monoterpenes/chemistry/metabolism Pheromones/*biosynthesis/*ch;"
Notes:		"MedlineSeybold, Steven J Tittiger, Claus eng Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review 2002/12/04 Annu Rev Entomol. 2003; 48:425-53. doi: 10.1146/annurev.ento.48.091801.112645. Epub 2002 Jun 4"