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Chem Biodivers

Title:		Hedge mustard (Sisymbrium officinale): chemical diversity of volatiles and their antimicrobial activity
Author(s):		Blazevic I; Radonic A; Mastelic J; Zekic M; Skocibusic M; Maravic A;
Address:		"Department of Organic Chemistry, Faculty of Chemistry and Technology, University of Split, N. Tesle 10/V, HR-21000 Split. ivica.blazevic@ktf-split.hr"
Journal Title:		Chem Biodivers
Year:		2010
Volume:		7
Issue:		8
Page Number:		2023 - 2034
DOI:		10.1002/cbdv.200900234
ISSN/ISBN:		1612-1880 (Electronic) 1612-1872 (Linking)
Abstract:		"Volatile compounds of hedge mustard (Sysimbrium officinale) have been investigated for the first time. Forthy-two compounds were identified after hydrodistillation (without or upon autolysis) after gas chromatography and gas chromatography/mass spectrometry analyses. In addition, after decoction and hydrolysis of O-glycosides, 18 volatile O-aglycones were identified. In general, the main volatiles found in hydrodistillates were: isopropyl isothiocyanate (27.6-48.9%), 2-methylpropanenitrile (0.5-18.8%), (Z)-hex-3-en-1-ol (0.5-18.0%), sec-butyl isothiocyanate (4.9-9.4%), (E)-hex-2-enal (3.5-8.6%), (Z)-hex-2-en-1-ol (0.3-8.4%), octanoic (0.5-8.6%) and dodecanoic acid (0-5.0%), 2-methylbutanenitrile (0-4.6%), dibutyl phthalate (0-4.5%), and ethyl linolenate (0-3.6%). The main volatile O-aglycones were: 2-phenylethyl alcohol (21.5%), 6,7-dehydro-7,8-dihydro-3-oxo-alpha-ionol (9.3%), eugenol (8.3%), benzyl alcohol (7.0%), ethyl vanillate (5.2%), 6-(tert-butyl)-5-methylphenol (5.1%), vanillin acetone (4.7%), ethyl 4-hydroxybenzoate (4.3%), and 2-hydroxy-beta-ionone (3.8%). All hydrodistillates exhibited great potential of antibacterial activity against five Gram-positive bacteria, nine ampicillin-resistant Gram-negative bacteria, and four fungi at a concentration of 500 microg/ml using the disc diffusion method"
Keywords:		"Anti-Infective Agents/*chemistry/pharmacology Bacteria/drug effects Fungi/drug effects Gas Chromatography-Mass Spectrometry Models, Chemical Mustard Plant/*chemistry Oils, Volatile/*chemistry/pharmacology;"
Notes:		"MedlineBlazevic, Ivica Radonic, Ani Mastelic, Josip Zekic, Marina Skocibusic, Mirjana Maravic, Ana eng Research Support, Non-U.S. Gov't Switzerland 2010/08/24 Chem Biodivers. 2010 Aug; 7(8):2023-34. doi: 10.1002/cbdv.200900234"