| Title: | Feeding state regulates pheromone-mediated avoidance behavior via the insulin signaling pathway in Caenorhabditis elegans |
| Author(s): | Ryu L; Cheon Y; Huh YH; Pyo S; Chinta S; Choi H; Butcher RA; Kim K; |
| Address: | "Department of Brain and Cognitive Sciences, DGIST, Daegu, Korea. Electron Microscopy Research Center, Korea Basic Science Institute, Cheongju-si, Chungcheongbuk-do, Korea. Department of Chemistry, University of Florida, Gainesville, FL, USA. Robotics Engineering Department, DGIST, Daegu, Korea. Department of Brain and Cognitive Sciences, DGIST, Daegu, Korea khkim@dgist.ac.kr" |
| ISSN/ISBN: | 1460-2075 (Electronic) 0261-4189 (Print) 0261-4189 (Linking) |
| Abstract: | "Animals change sensory responses and their eventual behaviors, depending on their internal metabolic status and external food availability. However, the mechanisms underlying feeding state-dependent behavioral changes remain undefined. Previous studies have shown that Caenorhabditis elegans hermaphrodite exhibits avoidance behaviors to acute exposure of a pheromone, ascr#3 (asc-DeltaC9, C9). Here, we show that the ascr#3 avoidance behavior is modulated by feeding state via the insulin signaling pathway. Starvation increases ascr#3 avoidance behavior, and loss-of-function mutations in daf-2 insulin-like receptor gene dampen this starvation-induced ascr#3 avoidance behavior. DAF-2 and its downstream signaling molecules, including the DAF-16 FOXO transcription factor, act in the ascr#3-sensing ADL neurons to regulate synaptic transmission to downstream target neurons, including the AVA command interneurons. Moreover, we found that starvation decreases the secretion of INS-18 insulin-like peptides from the intestine, which antagonizes DAF-2 function in the ADL neurons. Altogether, this study provides insights about the molecular communication between intestine and sensory neurons delivering hunger message to sensory neurons, which regulates avoidance behavior from pheromones to facilitate survival chance" |
| Keywords: | Animals Avoidance Learning/*physiology Caenorhabditis elegans/*metabolism Caenorhabditis elegans Proteins/genetics/*metabolism Forkhead Transcription Factors/genetics Insulin/*metabolism Neurons/metabolism Peptide Hormones/metabolism Pheromones/metabolism; |
| Notes: | "MedlineRyu, Leesun Cheon, YongJin Huh, Yang Hoon Pyo, Seondong Chinta, Satya Choi, Hongsoo Butcher, Rebecca A Kim, Kyuhyung eng K99 GM087533/GM/NIGMS NIH HHS/ P40 OD010440/OD/NIH HHS/ R00 GM087533/GM/NIGMS NIH HHS/ R01 GM118775/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2018/06/22 EMBO J. 2018 Aug 1; 37(15):e98402. doi: 10.15252/embj.201798402. Epub 2018 Jun 19" |
