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Environ Sci Technol

Title:		Analysis of volatile organic compounds in mainstream cigarette smoke
Author(s):		Polzin GM; Kosa-Maines RE; Ashley DL; Watson CH;
Address:		"Emergency Response and Air Toxicants Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, USA. GPolzin@cdc.gov"
Journal Title:		Environ Sci Technol
Year:		2007
Volume:		41
Issue:		4
Page Number:		1297 - 1302
DOI:		10.1021/es060609l
ISSN/ISBN:		0013-936X (Print) 0013-936X (Linking)
Abstract:		"Mainstream cigarette smoke is a complex aerosol containing more than 4400 chemicals. The proliferation of new brands has necessitated development of faster and more reliable methods capable of analyzing a wide range of compounds in cigarette smoke. Although the International Agency for Research on Cancer has classified whole cigarette smoke as a human carcinogen, many of the individual chemicals are themselves highly biologically active as carcinogens, teratogens, or have implications for cardiovascular disease. Among these chemicals are many volatile organic compounds (VOCs), e.g., benzene, ethylbenzene, and styrene. To analyze VOCs in mainstream cigarette smoke, we developed a novel headspace collection technique using polyvinylfluoride bags for sample collection followed by cannula transfer to evacuated standard 20-mL auto sampler vials. Coupling collection of the vapor-phase cigarette smoke with automated analysis by solid-phase microextraction and gas chromatography/mass spectrometry enabled us to routinely quantify selected VOCs in mainstream cigarette smoke. This technique has similar reproducibility to previous cold trap and impinger collection methods with significantly higher sample throughput and virtually no solvent waste. In this report we demonstrate the method's analytical capabilities by quantitatively analyzing 13 selected VOCs in mainstream cigarette smoke from top-selling domestic brands"
Keywords:		Benzene/*analysis Benzene Derivatives/*analysis Ketones/*analysis Smoke/*analysis *Tobacco Volatilization;
Notes:		"MedlinePolzin, Gregory M Kosa-Maines, Rachel E Ashley, David L Watson, Clifford H eng 2007/06/28 Environ Sci Technol. 2007 Feb 15; 41(4):1297-302. doi: 10.1021/es060609l"