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Allergy

Title:		Exposure to indoor endocrine-disrupting chemicals and childhood asthma and obesity
Author(s):		Paciencia I; Cavaleiro Rufo J; Silva D; Martins C; Mendes F; Farraia M; Delgado L; De Oliveira Fernandes E; Padrao P; Moreira P; Severo M; Barros H; Moreira A;
Address:		"Servico de Imunologia Basica e Clinica, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto, Porto, Portugal & Centro Hospitalar Sao Joao, Porto, Portugal. Institute of Science and Innovation in Mechanical Engineering and Industrial Management (INEGI), Porto, Portugal. EPIUnit, Instituto de Saude Publica, Universidade do Porto, Porto, Portugal. Faculdade de Ciencias da Nutricao e, Alimentacao da Universidade do Porto, Porto, Portugal. Departamento de Epidemiologia Clinica, Medicina Preditiva e Saude Publica da Faculdade de Medicina da Universidade do Porto, Porto, Portugal"
Journal Title:		Allergy
Year:		2019
Volume:		20190305
Issue:		7
Page Number:		1277 - 1291
DOI:		10.1111/all.13740
ISSN/ISBN:		1398-9995 (Electronic) 0105-4538 (Linking)
Abstract:		"BACKGROUND: Indoor air contaminants may act as endocrine-disrupting chemicals (EDCs). However, to what extent these contaminants affect health is poorly known. We aimed to assess the association between EDCs exposure and asthma, respiratory symptoms and obesity in schoolchildren. METHODS: Data from a cross-sectional analysis of 815 participants from 20 schools in Porto, Portugal, were analysed. Symptoms were assessed, asthma was defined on lung function, and airway reversibility and body mass index (BMI) were calculated. The concentrations of 13 volatile organic compounds and 2 aldehydes identified as EDCs were measured in 71 classrooms throughout 1 week. Principal component analysis (PCA) was used to assess the effect of co-exposure. Associations were estimated by regression coefficients using linear and logistic regression models. RESULTS: Increased individual and combined EDCs levels were found in classrooms having more children with asthma and obesity. Higher levels of hexane, styrene, cyclohexanone, butylated hydroxytoluene and 2-butoxyethanol were associated with obesity, and higher levels of cyclohexanone were associated with increased child BMI. Toluene, o-xylene, m/p-xylene and ethylbenzene were significantly associated with nasal obstruction. A positive association was found between PC1 and the risk of obese asthma (OR = 1.43, 95% CI 1.01, 1.98) and between PC2 and overweight (OR = 1.51, 95% CI 1.28, 1.79). PC1 and PC2 were also associated with nasal obstruction, and PC2 was associated with breathing difficulties and lean body mass, although EDCs concentrations were low. CONCLUSIONS: Our findings further support the role of EDCs in asthma and obesity development. Moreover, even low levels of indoor exposure may influence the risk of asthma, respiratory symptoms and obesity"
Keywords:		"Air Pollutants Air Pollution, Indoor/*adverse effects Asthma/complications/diagnosis/*epidemiology/*etiology Autonomic Nervous System/metabolism/physiopathology Child Disease Susceptibility Endocrine Disruptors/*adverse effects Environmental Exposure/*adv;"
Notes:		"MedlinePaciencia, Ines Cavaleiro Rufo, Joao Silva, Diana Martins, Carla Mendes, Francisca Farraia, Mariana Delgado, Luis de Oliveira Fernandes, Eduardo Padrao, Patricia Moreira, Pedro Severo, Milton Barros, Henrique Moreira, Andre eng EXALAR 21 project financed by FEDER/FNR and by Fun/Fundacao para a Ciencia e a Tecnologia/International Project NORTE-01-0145-FEDER-000010 - Health, Com/European Regional Development Fund/International SFRH/BD/108605/2015/Fundacao para a Ciencia e Tecnologia/International SFRH/BD/112269/2015/Fundacao para a Ciencia e Tecnologia/International Research Support, Non-U.S. Gov't Denmark 2019/02/12 Allergy. 2019 Jul; 74(7):1277-1291. doi: 10.1111/all.13740. Epub 2019 Mar 5"