| Title: | "2,3-Dihydrofurans as Potential Cytotoxic and Antibacterial Agents: Tandem Knoevenagel-Michael Cyclization for the Synthesis of 2,3-Dihydrofurans by Using alpha-Tosyloxy Ketone Precursors" |
| Author(s): | Kashanna J; Kumar RA; Kishore R; Kumar DN; Kumar AS; |
| Address: | "Department of Chemistry, Rajiv Gandhi University of Knowledge Technologies, Basar, 504107, India. Semiochemical Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500007, India. Department of Chemistry, GITAM University, Visakhapatnam, 530045, India. Process Chemistry Department, NIPER, Hyerabad, 500037, India" |
| ISSN/ISBN: | 1612-1880 (Electronic) 1612-1872 (Linking) |
| Abstract: | "Novel 2,3-dihydrofuran derivatives were synthesized through a tandem Knoevenagel-Michael cyclization in good yield by reacting alpha-tosyloxy ketone, 5,5-dimethyl-1,3-cyclohexanedione, and various aldehydes in the presence of phthalazine in acetonitrile. These compounds were subjected to in vitro antibacterial screening against eight micro-organisms by using diffusion method and also in vitro cytotoxicity screening against four human cancerous cell lines by applying MTT assay. Some of the compounds showed impressive activities" |
| Keywords: | "Anti-Bacterial Agents/chemical synthesis/chemistry/*pharmacology Antineoplastic Agents, Phytogenic/chemical synthesis/chemistry/*pharmacology Bacteria/*drug effects Cell Line, Tumor Cell Proliferation/drug effects Cyclization Dose-Response Relationship, D;" |
| Notes: | "MedlineKashanna, Jajula Kumar, Rathod Aravind Kishore, Ravada Kumar, Duddukuri Nandan Kumar, Alleni Suman eng Switzerland 2018/09/07 Chem Biodivers. 2018 Nov; 15(11):e1800277. doi: 10.1002/cbdv.201800277. Epub 2018 Oct 26" |
