| Title: | Micro-fabricated packed metal gas preconcentrator for enhanced monitoring of ultralow concentration of isoprene |
| Author(s): | Han B; Wang H; Huang H; Liu T; Wu G; Wang J; |
| Address: | "School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China; State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China. School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China; State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China. Electronic address: whairong@mail.xjtu.edu.cn" |
| DOI: | 10.1016/j.chroma.2018.08.058 |
| ISSN/ISBN: | 1873-3778 (Electronic) 0021-9673 (Linking) |
| Abstract: | "A novel non-silicon-based micro-preconcentration device, as a pretreatment component in a portable gas chromatography system, was developed for the preconcentration one of the trace volatile organic compounds (VOCs) in the exhaled gases, which is one typical biomarker for the chronic liver disease (CLD). The device was designed as an array of manifold-shaped rectangular metal micro-channels with flat dimensions of 16 mm x 12.6 mm and the internal empty volume is 14.4 muL on the copper substrate. Instead of the non-silicon fabrication process, the traditional laser etching technology (LET) was optimized to etch micro-channels, and vacuum diffusion welding (VDW) was applied to form internal channels. The fabricated chip was filled with Carbopack X adsorbent. In the testing, the metal gas preconcentrator (MGP) was installed in a commercial GC (gas chromatography) and nitrogen was used as carrier gas and desorbed gas. With the MPG, up to 352 of concentration factor can be achieved for 10 ppb isoprene. The developed MGP, which has advantages of high strength, low cost, good thermal conductivities, can potentially be used for non-invasive screening of advanced liver fibrosis by monitoring isoprene concentrations in exhaled breath" |
| Keywords: | "Breath Tests/*instrumentation/*methods Butadienes/*analysis/isolation & purification Chromatography, Gas End Stage Liver Disease/diagnosis Gases/*chemistry Hemiterpenes/*analysis/isolation & purification Humans Lasers Metals/chemistry Pentanes/*analysis/i;" |
| Notes: | "MedlineHan, Baoqing Wang, Hairong Huang, Hao Liu, Tinghan Wu, Guishan Wang, Jiuhong eng Netherlands 2018/09/10 J Chromatogr A. 2018 Oct 19; 1572:27-36. doi: 10.1016/j.chroma.2018.08.058. Epub 2018 Aug 31" |
