| Title: | Sexual deprivation increases ethanol intake in Drosophila |
| Author(s): | Shohat-Ophir G; Kaun KR; Azanchi R; Mohammed H; Heberlein U; |
| Address: | "Department of Anatomy, University of California, San Francisco, CA 94143-2822, USA. shohatophirg@janelia.hhmi.org" |
| ISSN/ISBN: | 1095-9203 (Electronic) 0036-8075 (Print) 0036-8075 (Linking) |
| Abstract: | "The brain's reward systems reinforce behaviors required for species survival, including sex, food consumption, and social interaction. Drugs of abuse co-opt these neural pathways, which can lead to addiction. Here, we used Drosophila melanogaster to investigate the relationship between natural and drug rewards. In males, mating increased, whereas sexual deprivation reduced, neuropeptide F (NPF) levels. Activation or inhibition of the NPF system in turn reduced or enhanced ethanol preference. These results thus link sexual experience, NPF system activity, and ethanol consumption. Artificial activation of NPF neurons was in itself rewarding and precluded the ability of ethanol to act as a reward. We propose that activity of the NPF-NPF receptor axis represents the state of the fly reward system and modifies behavior accordingly" |
| Keywords: | "Acetates/pharmacology Alcohol Drinking Animals Behavior, Addictive *Behavior, Animal Cohort Studies Conditioning, Psychological Cues Drosophila Proteins/genetics/*metabolism Drosophila melanogaster/*physiology Ethanol/*administration & dosage Female Ion C;" |
| Notes: | "MedlineShohat-Ophir, G Kaun, K R Azanchi, R Mohammed, H Heberlein, U eng R01 AA010035/AA/NIAAA NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2012/03/17 Science. 2012 Mar 16; 335(6074):1351-5. doi: 10.1126/science.1215932" |
