| Title: | Multi-capillary column high-pressure photoionization time-of-flight mass spectrometry and its application for online rapid analysis of flavor compounds |
| Author(s): | Chen X; Hua L; Jiang J; Hu F; Wan N; Li H; |
| Address: | "Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, Liaoning, 116023, People's Republic of China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, People's Republic of China. Electronic address: hli@dicp.ac.cn. Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, Liaoning, 116023, People's Republic of China. Henan Province Medical Instrument Testing Institute, 79 Xiongerhe Road, Zhengzhou, 450018, People's Republic of China. Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, Liaoning, 116023, People's Republic of China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, People's Republic of China" |
| DOI: | 10.1016/j.talanta.2019.03.103 |
| ISSN/ISBN: | 1873-3573 (Electronic) 0039-9140 (Linking) |
| Abstract: | "High-pressure photoionization time-of-flight mass spectrometry (HPPI-TOFMS) is a versatile and highly sensitive analytical technique for online and real-time analysis of trace volatile organic compounds in complex mixtures. However, discrimination of isomers is usually a great challenge for the soft ionization method, and matrix effect is also inevitable under high pressure in the HPPI source. In this work, we describe a first attempt to develop a two-dimensional (2D) hyphenated instrument by coupling of a multi-capillary column (MCC) with a HPPI-TOFMS to overcome these problems. The capability of the MCC-HPPI-TOFMS for discrimination of isomeric compounds and elimination of the matrix effect was demonstrated by analyzing flavor mixtures. With the merits of fast separation, soft ionization and high detection sensitivity, satisfactory effects in the 2D analysis were achieved, despite the relatively low chromatographic resolution of MCC. As a result, three isomers, eucalyptol, l-menthone and linalool, in a flavor mixture were successfully categorized within 90?ª+s, and the matrix effect caused by solvent ethanol was significantly eliminated as well. The limits of detection (LODs) down to sub-ppbv level were achieved for the investigated five flavor compounds without any enrichment process, and an excellent repeatability was obtained with the relative standard deviations (RSDs) of signal intensities |
| Keywords: | Flavor compounds High-pressure photoionization time-of-flight mass-spectrometry Isomer separation Matrix effect Multi-capillary column Rapid analysis; |
| Notes: | "PubMed-not-MEDLINEChen, Xuan Hua, Lei Jiang, Jichun Hu, Fan Wan, Ningbo Li, Haiyang eng Netherlands 2019/05/28 Talanta. 2019 Aug 15; 201:33-39. doi: 10.1016/j.talanta.2019.03.103. Epub 2019 Mar 30" |
