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Nat Rev Neurosci

Title:		Olfactory signalling in vertebrates and insects: differences and commonalities
Author(s):		Kaupp UB;
Address:		"Center of Advanced European Studies and Research, Ludwig-Erhard-Allee 2, Bonn, Germany. u.b.kaupp@caesar.de"
Journal Title:		Nat Rev Neurosci
Year:		2010
Volume:		20100210
Issue:		3
Page Number:		188 - 200
DOI:		10.1038/nrn2789
ISSN/ISBN:		1471-0048 (Electronic) 1471-003X (Linking)
Abstract:		"Vertebrates and insects have evolved complex repertoires of chemosensory receptors to detect and distinguish odours. With a few exceptions, vertebrate chemosensory receptors belong to the family of G protein-coupled receptors that initiate a cascade of cellular signalling events and thereby electrically excite the neuron. Insect receptors, which are structurally and genetically unrelated to vertebrate receptors, are a complex of two distinct molecules that serves both as a receptor for the odorant and as an ion channel that is gated by binding of the odorant. Metabotropic signalling in vertebrates provides a rich panoply of positive and negative regulation, whereas ionotropic signalling in insects enhances processing speed"
Keywords:		"Animals Insecta/*physiology Odorants Olfactory Pathways/*physiology Olfactory Receptor Neurons/*physiology Pheromones Receptors, Odorant/*physiology Signal Transduction/physiology Smell/physiology Vertebrates/*physiology;"
Notes:		"MedlineKaupp, U Benjamin eng Review England 2010/02/11 Nat Rev Neurosci. 2010 Mar; 11(3):188-200. doi: 10.1038/nrn2789. Epub 2010 Feb 10"