| Title: | Breath volatile organic compound analysis: an emerging method for gastric cancer detection |
| Author(s): | Zhang J; Tian Y; Luo Z; Qian C; Li W; Duan Y; |
| Address: | "Research Center of Analytical Instrumentation, Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, People's Republic of China. Shaanxi Key Laboratory of Earth Surface System and Environmental Carrying Capacity, College of Urban and Environmental Sciences, Northwest University, Xi'an 710127, People's Republic of China. West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, People's Republic of China" |
| ISSN/ISBN: | 1752-7163 (Electronic) 1752-7155 (Linking) |
| Abstract: | "Gastric cancer is a common malignancy, being the fifth most frequently diagnosed cancer and the fourth leading cause of cancer-related deaths worldwide. Diagnosis of gastric cancer at the early stage is critical to effectively improve the survival rate. However, a substantial proportion of patients with gastric cancer in the early stages lack specific symptoms or are asymptomatic. Moreover, the imaging techniques currently used for gastric cancer screening, such as computed tomography and barium examination, are usually radioactive and have low sensitivity and specificity. Even though endoscopy has high accuracy for gastric cancer screening, its application is limited by the invasiveness of the technique. Breath analysis is an economic, effective, easy to perform, non-invasive detection method, and has no undesirable side effects on subjects. Extensive worldwide research has been conducted on breath volatile organic compounds (VOCs), which reveals its prospect as a potential method for gastric cancer detection. Many interesting results have been obtained and innovative methods have been introduced in this subject; hence, an extensive review would be beneficial. By providing a comprehensive list of breath VOCs identified by gastric cancer would promote further research in this field. This review summarizes the commonly used technologies for exhaled breath analysis, focusing on the application of analytical instruments in the detection of breath VOCs in gastric cancers, and the alterations in the profile of breath biomarkers in gastric cancer patients are discussed as well" |
| Keywords: | Breath Tests Early Detection of Cancer Exhalation Humans *Stomach Neoplasms/diagnostic imaging *Volatile Organic Compounds biomarker exhaled breath gastric cancer mass spectrometry; |
| Notes: | "MedlineZhang, Jing Tian, Yonghui Luo, Zewei Qian, Cheng Li, Wenwen Duan, Yixiang eng Research Support, Non-U.S. Gov't Review England 2021/10/06 J Breath Res. 2021 Oct 20; 15(4). doi: 10.1088/1752-7163/ac2cde" |
